WH0004149M1

Monoclonal Anti-MAX antibody produced in mouse

clone 4E10-1A9, purified immunoglobulin, buffered aqueous solution

• Sinonimo/i: Anti-MGC10775, Anti-MGC11225, Anti-MGC18164, Anti-MGC34679, Anti-MGC36767, Anti-MYC associated factor X, Anti-orf1
• Numero MDL: MFCD01633623
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 4E10-1A9, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• tecniche: immunofluorescence: suitable; indirect ELISA: suitable; proximity ligation assay: suitable; western blot: 1-5 μg/mL
• Isotipo: IgG2aκ
• N° accesso Genebanck: BC003525
• N° accesso UniProt: P61244
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... MAX(4149)

Descrizione

Descrizione generale

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown. (provided by RefSeq)

Immunogeno

MAX (AAH03525, 1 a.a. ~ 151 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS

Azioni biochim/fisiol

Myc-associated factor X (MAX) interacts with N-, L-, and c-Myc proteins both in vitro and in vivo. MAX plays a vital role in the regulation of the MYC/MAX/ MAX dimerization protein (MXD) network of basic helix-loop-helix leucine zipper (bHLHZip) transcription factors implicated in cell proliferation, differentiation, and apoptosis. Mutation of the gene leads to pheochromocytomas and paragangliomas (PPGLs). Heterodimer complex of c-Myc and Max proteins stimulates the transcription at target promoters by binding hexameric DNA consensus sequences “CANNTG” (E-boxes). Apart from this, Max hinders MYC-dependent cell transformation by transcriptional repression of the same E-boxes by associating with various repressors such as MXD, MAX network transcriptional repressor (MNT), and MAX gene-associated protein (MGA). Gene transcription activated by MYC–MAX heterodimers can be repressed by Max homodimers by decreasing the level of free MAX monomers and by binding to E-box DNA sequences.

Stato fisico

Solution in phosphate buffered saline, pH 7.4

Note legali

GenBank is a registered trademark of United States Department of Health and Human Services

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)