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T5771

Sigma-Aldrich

Testosterone 3-(O-carboxymethyl)oxime: BSA - fluorescein isothiocyanate conjugate

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5 MG
440,00 €

440,00 €

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5 MG
440,00 €

About This Item

Numero MDL:
MFCD00132415
Codice UNSPSC:
51111800
NACRES:
NA.77

440,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Richiedi un ordine bulk

Saggio

≥98.00% (TLC)

Livello qualitativo

200

Stato

powder

Controllo stupefacenti

regulated under CDSA - not available from Sigma-Aldrich Canada

Grado di funzionalizzazione

~3 mol FITC per mol BSA
~10 mol steroid per mol BSA

tecniche

flow cytometry: suitable

Solubilità

water: 1.90-2.10 mg/mL, clear to faintly hazy, orange

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

Applicazioni

Testosterone 3-(O-carboxymethyl)oxime: BSA-FITC has been used for flow cytometric assays in serum-free cell cultures2. It has also been used for fluorescence labeling experiments in L6 cells3.

Azioni biochim/fisiol

Studies have reported that BSA-coupled testosterone can block the growth of LNCaP cells. Furthermore, it can activate Fas protein and cell death, as well as reduce the translocation, adhesion and incursion of iAR-negative, DU145 prostate cancer cells2.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 + H312 + H332,H351

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
017M4099V
13161013
059K4059
077K4026
034F4061

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Supelco

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Fluorescein isothiocyanate isomer I suitable for protein labeling, ≥90% (HPLC), powder

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F7250

Fluorescein isothiocyanate isomer I

Sieroalbumina lyophilized powder, ≥96% (agarose gel electrophoresis)

Sigma-Aldrich

A2153

Sieroalbumina

Rui Fu et al.
Journal of cellular physiology, 227(1), 98-107 (2011-03-05)
Androgens are known to modulate the skeletal muscle proliferation and differentiation processes. Recent in vitro studies have shown that dihydrotestosterone and anabolic steroids have functions in promoting the proliferation and differentiation of the mouse skeletal muscle myoblast C2C12 cell line
Anastassia Hatzoglou et al.
The Journal of clinical endocrinology and metabolism, 90(2), 893-903 (2004-12-09)
Nongenomic androgen actions imply mechanisms different from the classical intracellular androgen receptor (iAR) activation. We have recently reported the identification of a membrane androgen receptor (mAR) on LNCaP human prostate cancer cells, mediating testosterone signal transduction within minutes. In the
Yizhou Zhang et al.
Aging, 11(8), 2281-2294 (2019-04-22)
The non-genomic actions of androgen-induced synaptic plasticity have been extensively studied. However, the underlying mechanisms remain controversial. We recently found that testosterone-fetal bovine serum albumin (T-BSA), a cell membrane-impermeable complex, led to a rapid increase in the postsynaptic density 95
Synthesis of fluorescein labelled steroid hormone-albumin conjugates for the fluorescent histochemical detection of hormone receptors.
E Gaetjens et al.
Journal of steroid biochemistry, 13(8), 1001-1003 (1980-08-01)
Sha Li et al.
Molecular and cellular endocrinology, 414, 82-90 (2015-07-15)
Testosterone (T), the principal androgen, and its metabolite, dihydrotestosterone (DHT), are known to mediate their effects through binding to intracellular androgen receptors (iARs). In addition to their well-known genomic effects, androgens rapidly alter neuronal excitability through a non-genomic pathway mediated

Domande

1–2 di 2 domande  

  1. How will you dissolve this product (T5771)?

    1 risposta

    1. This product is soluble in water at approximately 2 mg/ml.

      Utile?

  2. How can I dissolve the products that arrived in solid form?

    1 risposta

    1. The spec sheet indicates that the product is tested for solubility at 2mg/ml in water. For Testosterone 3-(O-carboxymethyl)oxime: BSA, solubility is tested in Phosphate buffer pH 7.5. Additionally, without the albumin conjugate, Testosterone 3-(O-carboxymethyl)oxime is soluble in ethanol at 50mg/ml.

      Utile?

Recensioni

Nessuna valutazione

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