SRP8044

CD40L, Soluble human

recombinant, expressed in CHO cells, FLAG^® tagged, >95% (SDS-PAGE)

• Sinonimo/i: ACRP30headless:CD154, ACRP30headless:CD40L, ACRP30headless:TNFSF5, ADIPOQ-CD40L
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Origine biologica: human
• Ricombinante: expressed in CHO cells
• Tag: FLAG^® tagged
• Saggio: >95% (SDS-PAGE)
• Stato: lyophilized
• PM: 35-40 kDa by SDS-PAGE
• Confezionamento: pkg of 10 μg
• Condizioni di stoccaggio: avoid repeated freeze/thaw cycles
• Impurezze: <0.01 EU/μg endotoxin, tested
• N° accesso UniProt: P29965
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... CD40LG(959)

Descrizione

Descrizione generale

CD40L (cluster of differentiation 40 ligand) belongs to the tumor necrosis factor (TNF) family, and is expressed by basophils, B cells, monocytic cells, natural killer cells, platelets, mast cells and T cells. It is predominantly expressed on pro-inflammatory T cells. It also exists in a soluble form.[1]

Azioni biochim/fisiol

CD40L (cluster of differentiation 40 ligand) is active in its membrane-bound form.[1] It interacts with CD40 and functions as a proinflammatory and procoagulant agent. The serum levels of soluble CD40L is elevated in malignant middle cerebral artery infarction (MMCAI) patients, especially in non-surviving patients.[2]

Stato fisico

Lyophilized from PBS

Ricostituzione

Reconstitute with 100 μL deionized water.

Altre note

Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG^®-tag.

Note legali

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable