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Documenti fondamentali

SML0545

Sigma-Aldrich

CID 1067700

≥98% (HPLC)

Sinonimo/i:

2-(Benzoylcarbamothioylamino)-5,5-dimethyl-4,7-dihydrothieno[2,3-c]pyran-3-carboxylic acid, 2-[[(Benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylic acid, CID-1067700, CID1067700, SID57578339

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5 MG
117,00 €
25 MG
470,00 €

117,00 €


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Cambia visualizzazione
5 MG
117,00 €
25 MG
470,00 €

About This Item

Formula empirica (notazione di Hill):
C18H18N2O4S2
Numero CAS:
Peso molecolare:
390.48
Codice UNSPSC:
12352200
NACRES:
NA.77

117,00 €


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Saggio

≥98% (HPLC)

Stato

powder

Colore

white to light brown

Solubilità

DMSO: 10 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

[s]1c2c(c(c1NC(=S)NC(=O)c3ccccc3)C(=O)O)CC(OC2)(C)C

InChI

1S/C18H18N2O4S2/c1-18(2)8-11-12(9-24-18)26-15(13(11)16(22)23)20-17(25)19-14(21)10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3,(H,22,23)(H2,19,20,21,25)
ATSWBWHRHAQVFM-UHFFFAOYSA-N

Azioni biochim/fisiol

CID 1067700 antagonizes ras-related protein Rab-7 and reduces class switch DNA recombination (CSR) in B cells and survival of plasma cells.[1]
CID 1067700 is a potent and competitive inhibitor of Ras-related GTPases that potently binds to Rab7 nucleotide binding site.
CID 1067700 is a potent and competitive inhibitor of Ras-related GTPases.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Autophagy dysfunction has been observed in intervertebral disc degeneration (IVDD) cells, a main contributing factor to cell death, but the precise role of autophagy during IVDD is still controversial. This study aimed to investigate the role of autophagy involved in
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O-GlcNAcylation is a form of posttranslational modification, and serves various functions, including modulation of location, stability, and activity for the modified proteins. O-linked-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential cellular enzyme that posttranslationally modifies the cellular proteins with O-GlcNAc moiety.
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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by motoneuron loss, for which there is currently no effective treatment. Statins, as inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, are used as drugs for treatment for a variety of disease such
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Glucosamine (GlcN), a dietary supplement widely utilized to promote joint health and effective in the treatment of osteoarthritis, is an effective macroautophagy/autophagy activator in vitro and in vivo. Previous studies have shown that autophagy is required for hepatitis B virus

Articoli

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Domande

  1. After resuspending 5 mg CID 1067700 in DMSO, should it still be stored at 4°C or should it be stored at -20°C?

    1 risposta
    1. The stability of this material in solution at 4°C has not been determined. Following reconstitution, aliquot and freeze at -20°C for up to 3 months.

      Utile?

Recensioni

Nessuna valutazione

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