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SML0517

Sigma-Aldrich

Amlexanox

≥98% (HPLC)

Sinonimo/i:

2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]Benzopyrano[2,3-b]pyridine-3-carboxylic acid, AA 673, Amoxanox, CHX 3673

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10 MG
114,00 €
50 MG
425,00 €

114,00 €

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10 MG
114,00 €
50 MG
425,00 €

About This Item

Formula empirica (notazione di Hill):
C16H14N2O4
Numero CAS:
68302-57-8
Peso molecolare:
298.29
Numero MDL:
MFCD00864790
Codice UNSPSC:
12352200
ID PubChem:
329825526
NACRES:
NA.77

114,00 €

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Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: 10 mg/mL at warmed, clear

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(O)=O

InChI

1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
SGRYPYWGNKJSDL-UHFFFAOYSA-N

Informazioni sul gene

human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

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Descrizione generale

Amlexanox is an anti-allergic drug with anti-inflammatory properties.[1]

Azioni biochim/fisiol

Amlexanox elevates the amount of nonsense-containing mRNAs in treated cells and helps to generate full-length proteins effectively.[1]
Amlexanox is an anti-allergy and anti-asthma drug that blocks histamine and leukotriene release from leukocytes and mast cells. Amlexanox has also been shown to inhibit cahaperone activity of Hsp90, and S100A13, which is involved in transport of proteins devoid of signal peptide sequences.
Amlexanox is an anti-allergy, anti-ulcer drug; S100A13 inhibitor.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000390398
0000383510
0000390398
0000383510
0000163464

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Sigma-Aldrich

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Shannon M Reilly et al.
Nature medicine, 19(3), 313-321 (2013-02-12)
Emerging evidence suggests that inflammation provides a link between obesity and insulin resistance. The noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) are induced in liver and fat by NF-κB activation upon high-fat diet feeding and in turn initiate
F Tarantini et al.
The Journal of biological chemistry, 276(7), 5147-5151 (2000-11-23)
Interleukin (IL)1alpha mediates proinflammatory events through its extracellular interaction with the IL1 type I receptor. However, IL1alpha does not contain a conventional signal peptide sequence that provides access to the endoplasmic reticulum-Golgi apparatus for secretion. Thus, we have studied the
Jie Liu et al.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 102(4), 475-481 (2006-09-26)
The objectives of this study were to clinically determine the topical efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulcerations (MiRAU) in a Chinese cohort. A randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial
B Murray et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 35(2), 117-122 (2006-01-25)
The study was designed to determine the efficacy of OraDisc (active component 2 mg amlexanox) on the prevention of aphthous ulcers treated at the prodromal stage. Thermographic imaging was used to confirm the presence of a prodromal ulcer. Fifty-two patients
Miki Okada et al.
Biochemical and biophysical research communications, 292(4), 1023-1030 (2002-04-12)
S100 proteins are a multigenic family of low-molecular-weight Ca(2+)-binding proteins comprising 19 members. These proteins undergo a conformational change by Ca(2+)-binding and consequently interact with their target proteins. Recently, we reported that two antiallergic drugs, Amlexanox and Cromolyn, bind to
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