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D2141

6-Diazo-5-oxo-L-norleucine

≥95% (HPLC), suitable for ligand binding assays

Sinonimo/i:

(S)-2-Amino-6-diazo-5-oxocaproic acid, DON

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Cambia visualizzazione
A voi/SKUDisponibilitàPrezzo
5 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
54,80 €
25 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
192,00 €

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C6H9N3O3
Numero CAS:
157-03-9
Peso molecolare:
171.15
NACRES:
NA.26
PubChem Substance ID:
24893639
UNSPSC Code:
12352209
MDL number:
MFCD00037218
Beilstein/REAXYS Number:
1725815

54,80 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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Nome del prodotto

6-Diazo-5-oxo-L-norleucine, powder

assay

≥95% (HPLC)

Quality Segment

200

form

powder

technique(s)

ligand binding assay: suitable

color

faint yellow, to yellow or tan

antibiotic activity spectrum

neoplastics

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O

InChI

1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1

InChI key

YCWQAMGASJSUIP-YFKPBYRVSA-N

General description

Chemical structure: amino acid derivatives

Application

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

Biochem/physiol Actions

6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.
DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.
DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.

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Questo articolo
A4142B8385C3909
6-Diazo-5-oxo-L-norleucine powder

Sigma-Aldrich

D2141

6-Diazo-5-oxo-L-norleucine

Azaserine ≥98% (TLC)

Sigma-Aldrich

A4142

Azaserine

Bestatin hydrochloride ≥98% (HPLC)

Sigma-Aldrich

B8385

Bestatin hydrochloride

D-Cycloserine synthetic

Sigma-Aldrich

C3909

D-Cycloserine

form

powder

form

powder

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

-

technique(s)

ligand binding assay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

100

Quality Level

300

Quality Level

200

color

faint yellow, to yellow or tan

color

off-white to yellow-green

color

-

color

-

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

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Domande

1–4 di 4 domande  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

  3. The 25mg comes a 25mg or 5 x 5mg ?

    1 risposta

    1. The 25mg pack size is 25 milligrams in a single HDPE bottle.

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  4. How does this come packaged? Is it a powder? How much comes in one allotment of 5mg?

    1 risposta

    1. This product comes packaged in a 4ml amber glass bottle and a red polypropylene cap. The end-user would receive 5mg of the 5mg pack size.

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