SML0278

SR 48692

≥98% (HPLC)

• Sinonimo/i: 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid, Meclinertant
• Formula empirica (notazione di Hill): C₃₂H₃₁ClN₄O₅
• Numero CAS: 146362-70-1
• Peso molecolare: 587.07
• Codice UNSPSC: 12352200
• ID PubChem: 329825286
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: ≥2 mg/mL (warmed)
• Temperatura di conservazione: −20°C
• Stringa SMILE: COc1cccc(OC)c1-c2cc(nn2-c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(C6)CC5C7)C(O)=O
• InChI: 1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40); DYLJVOXRWLXDIG-UHFFFAOYSA-N
• Informazioni sul gene: human ... NTSR1(4923)

Descrizione

Applicazioni

SR 48692 has been used as a neurotensin high-affinity receptor 1 (NTSR1) antagonist:

• to explore the function of NTSR1 in glioblastoma (GBM) cells[1]
• to determine the roles of neurotensin (NT) in the regulation of bile acid (BA) uptake, in vivo[2]
• to explore the involvement of NTSR1 versus NTSR2 in mice[3]

Azioni biochim/fisiol

SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.

SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist.

Caratteristiche e vantaggi

This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable