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N5266

Sigma-Aldrich

Neurotensin Fragment 8-13 acetate salt

≥97% (HPLC), suitable for ligand binding assays

Sinonimo/i:

L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

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About This Item

Formula empirica (notazione di Hill):
C38H64N12O8
Numero CAS:
60482-95-3
Peso molecolare:
816.99
Numero MDL:
MFCD00076686
Codice UNSPSC:
12352209
ID PubChem:
24897727
NACRES:
NA.26

product name

Neurotensin Fragment 8-13 acetate salt, ≥97% (HPLC)

Saggio

≥97% (HPLC)

Forma fisica

powder

tecniche

ligand binding assay: suitable

Colore

white

applicazioni

cell analysis

Temperatura di conservazione

−20°C

Stringa SMILE

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C(N)CCCNC(N)=N)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C38H64N12O8/c1-5-22(4)30(34(55)48-28(36(57)58)19-21(2)3)49-32(53)27(20-23-12-14-24(51)15-13-23)47-33(54)29-11-8-18-50(29)35(56)26(10-7-17-45-38(42)43)46-31(52)25(39)9-6-16-44-37(40)41/h12-15,21-22,25-30,51H,5-11,16-20,39H2,1-4H3,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H,57,58)(H4,40,41,44)(H4,42,43,45)
DQDBCHHEIKQPJD-UHFFFAOYSA-N

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Categorie correlate

Amino Acid Sequence

Arg-Arg-Pro-Tyr-Ile-Leu

Azioni biochim/fisiol

Neurotensin Fragment 8-13 acetate salt is the smallest active fragment of neurotensin.

Linkage

Smallest active fragment of neurotensin

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Shifei Xia et al.
Electrophoresis, 28(18), 3268-3276 (2007-09-15)
A new method for the determination of the peptide hormones of brain and intestine based on CE coupling with a DAD and ESI-MS was established. Several electrophoretic and ESI-MS parameters were investigated in detail, such as electrolyte nature and concentration
Veronique Maes et al.
Journal of medicinal chemistry, 49(5), 1833-1836 (2006-03-03)
Two new 99mTc-labeled neurotensin(8-13) analogues containing the retro-N(alpha)-carboxymethyl-histidine ((N(alpha)His)Ac) chelator were synthesized as potential radiopharmaceuticals for visualization of pancreatic carcinoma. To improve the pharmacokinetic properties, (N(alpha)His)Ac-Arg-NMeArg-Pro-Tyr-Tle-Leu (NT-XII), which is metabolically stabilized at two positions, was further modified. Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic
Kyle P Kokko et al.
Journal of medicinal chemistry, 46(19), 4141-4148 (2003-09-05)
A set of neurotensin[8-13] (NT[8-13]) analogues featuring substitution of non-natural cationic amino acids in the Arg(8) position have been synthesized and tested for binding potencies against the three cloned human NT receptors (hNTR-1, hNTR-2, hNTR-3), functional agonism of the hNTR1
Rodrigo Teodoro et al.
Nuclear medicine and biology, 38(1), 113-120 (2011-01-12)
Several strategies on the development of radiopharmaceuticals have been employed. Bifunctional chelators seem to be a promising approach since high radiochemical yields as well as good in vitro and in vivo stability have been achieved. To date, neurotensin analogs have
Florine Cavelier et al.
Journal of the American Chemical Society, 124(12), 2917-2923 (2002-03-21)
The analogue gamma-(dimethylsila)-proline, denoted silaproline (Sip), was synthesized in both enantiomerically pure forms by diastereoselective alkylation of a chiral glycine equivalent with use of Schöllkopf's bis-lactim ether method. The effect of replacing a proline residue in model peptides by this
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