Stock solutions of Resiquimod in DMSO or ethanol may be stored at -20°C for a maximum duration of 2 months.
SML0196
Resiquimod
≥98% (HPLC), powder, TLR7/TLR8 agonist
Sinonimo/i:
4-Amino-2-(ethoxymethyl)-alpha, R-848, R848, S28463, alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol
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10 MG
117,00 €
50 MG
488,00 €
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Cambia visualizzazione
10 MG
117,00 €
50 MG
488,00 €
About This Item
Formula empirica (notazione di Hill):
C17H22N4O2
Numero CAS:
Peso molecolare:
314.38
Numero MDL:
Codice UNSPSC:
51111800
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Resiquimod, ≥98% (HPLC)
Saggio
≥98% (HPLC)
Stato
powder
Condizioni di stoccaggio
desiccated
protect from light
Colore
white to tan
Solubilità
DMSO: 10 mg/mL, clear (warmed to 60 °C)
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Stringa SMILE
CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
InChI
1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
BXNMTOQRYBFHNZ-UHFFFAOYSA-N
Applicazioni
Resiquimod has been used in the stimulation of bone marrow-derived dendritic cells (BMDCs) stimulation([1] and B cells.[2] It has also been used as a ligand for toll-like receptors (TLR7) in malignant melanoma cell line B16F10.[3][4]
Resiquimod may be used in immunological and cancer-related cell signaling studies.
Azioni biochim/fisiol
Resiquimod (R-848) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and antitumoral activities.
Resiquimod belongs to the class of imidazoquinolinamines compounds with immunomodulatory effects. Resiquimod increases the levels of cytokines such as TNF-α, IL-6 and IFN-α.[5][6]
Resiquimod is 314.4 Da molecule which elicits immune function during visceral infection with L. infantum Sp. It mediates the trafficking of granulocytes, macrophages, leukocytes and dendritic cells.[7] It is a recommended topical drug for treating skin tumors like actinic keratosis (AK) and superficial basal cell carcinoma.[8]
Resiquimod is an agonist of toll-like receptor 7 and 8 (TLR- and TLR-8).
Caratteristiche e vantaggi
This compound is featured on the Cytokine Receptors (Interleukin-1 Receptor/TIR Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Articoli
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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