Factor VIIa is a serine protease involved in the blood coagulation cascade. The activity of Factor VIIa can be assayed with chromogenic substrate MeSO2-Cha-Abu-Arg-pNA or the flourogenic substrate MeSO2-Cha-Abu-Arg-AFC.
Seminars in thrombosis and hemostasis, 35(1), 9-22 (2009-03-25)
Hemostasis is traditionally defined as the physiologic process whereby bleeding is antagonized and possibly stopped to minimize blood loss. The first medical description of the clinical and inherited features of hemostasis can be dated back more than 1000 years, when
Thrombosis and haemostasis, 88(5), 750-755 (2002-11-13)
Factor VII (FVII) requires the cleavage of an internal peptide bond and the association with tissue factor (TF) to attain its fully active FVIIa conformation. This event alone leaves FVIIa in a zymogen-like state of relatively low specific activity. The
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