SBR00038

Hygromycin B

Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus

• Formula empirica (notazione di Hill): C₂₀H₃₇N₃O₁₃
• Numero CAS: 31282-04-9
• Peso molecolare: 527.52
• Codice UNSPSC: 51281624
• NACRES: NA.76

Proprietà

• Nome del prodotto: Hygromycin B, Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus
• Origine biologica: Streptomyces hygroscopicus
• Livello qualitativo: 200
• Stato: solid
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria; fungi; viruses
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: N([C@@H]1[C@H]([C@@H]([C@H]([C@@H](C1)N)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]3O[C@@]4(O[C@@H]32)O[C@@H]([C@@H]([C@@H]([C@H]4O)O)O)[C@H](N)CO)O)CO)O)C
• InChI: 1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1; GRRNUXAQVGOGFE-XKIAHZFYSA-N

Descrizione

Descrizione generale

Chemical structure: aminoglycoside

Applicazioni

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

Azioni biochim/fisiol

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H310 + H330
• Consigli di prudenza: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Classi di pericolo: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable