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SAB4504429

Sigma-Aldrich

Anti-phospho-Histone H3.1 (pSer10) antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-H3.1, Anti-H3/c, Anti-H3C1, Anti-H3C10, Anti-H3C11, Anti-H3C12, Anti-H3C2, Anti-H3C4, Anti-H3C6, Anti-H3C8, Anti-H3FC, Anti-HIST1H3C

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 15 kDa

Reattività contro le specie

human, rat, mouse

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P68431
P84243
Q71DI3

N° accesso UniProt

P68431

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

phosphorylation (pSer10)

Informazioni sul gene

human ... HIST1H3A(8350) , HIST1H3B(8358) , HIST1H3C(8352) , HIST1H3D(8351) , HIST1H3E(8353) , HIST1H3G(8355) , HIST1H3H(8357) , HIST1H3I(8354) , HIST1H3J(8356) , HIST1H4A(8359)

Descrizione generale

Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A). H3.1 is also called as HIST1H3E. It is mainly expressed in the S phase. HIST1H3E is located on human chromosome 6p22.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Histone H3.1 around the phosphorylation site of Ser10.

Immunogen Range: 1-50

Azioni biochim/fisiol

Histone proteins are basic building blocks of chromatin. Mutations in histone H3 results in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that drive chromatin condensation. H3.1 acts as a replication-dependent histone.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Mario A Miranda et al.
Physiological reports, 8(20), e14573-e14573 (2020-10-29)
Maintenance of functional β-cell mass is critical to preventing diabetes, but the physiological mechanisms that cause β-cell populations to thrive or fail in the context of obesity are unknown. High fat-fed SM/J mice spontaneously transition from hyperglycemic-obese to normoglycemic-obese with
A Comprehensive View of the Epigenetic Landscape Part I: DNA Methylation, Passive and Active DNA Demethylation Pathways and Histone Variants.
Sadakierska-Chudy A, et al.
Neurotoxicity Research, 27(1), 84?97-84?97 (2015)
Navrita Mathiah et al.
EMBO reports, 21(11), e50944-e50944 (2020-10-06)
At gastrulation, a subpopulation of epiblast cells constitutes a transient posteriorly located structure called the primitive streak, where cells that undergo epithelial-mesenchymal transition make up the mesoderm and endoderm lineages. Mouse embryo epiblast cells were labelled ubiquitously or in a
Selective methylation of histone H3 variant H3. 1 regulates heterochromatin replication.
Jacob Y, et al.
Science, 343(6176), 1249-1253 (2014)
Evangéline Despin-Guitard et al.
Nature communications, 15(1), 7364-7364 (2024-08-31)
During the epithelial-mesenchymal transition driving mouse embryo gastrulation, cells divide more frequently at the primitive streak, and half of those divisions happen away from the apical pole. These observations suggest that non-apical mitoses might play a role in cell delamination.
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