S2064

SC-560

≥98% (HPLC)

• Sinonimo/i: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethyl pyrazole
• Formula empirica (notazione di Hill): C₁₇H₁₂ON₂ClF₃
• Numero CAS: 188817-13-2
• Peso molecolare: 352.74
• Numero MDL: MFCD02179214
• Codice UNSPSC: 51111800
• ID PubChem: 24278696
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Solubilità: DMSO: >20 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: COc1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F
• InChI: 1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3; PQUGCKBLVKJMNT-UHFFFAOYSA-N
• Informazioni sul gene: human ... PTGS1(5742) , PTGS2(5743)

Descrizione

Applicazioni

SC-560 has been used as a cyclooxygenase-1 (COX-1) inhibitor to study its effects on prostaglandin E-2 (PGE2) signaling in ciliogenesis in zebrafish embryos.[1] It has also been used as a selective inhibitor of COX-1 to study its role in PM10-induced endothelial dysfunction.[2]

Azioni biochim/fisiol

SC-560 (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole) is a non-steroidal anti-inflammatory drug (NSAID).[3] It is a lipophilic, diaryl heterocyclic compound.[4] SC-560 acts as an effective antiviral agent against hepatitis C virus (HCV).[5] It also has a potential to hinder prostaglandin E2 synthesis in neurons at nanomolar concentrations.[6]

SC-560 belongs to the diaryl heterocycle class of cyclooxygenase (COX) inhibitors. It exhibits anti-tumor and anti-proliferative activities.[7]

Selective cyclooxygenase-1 (COX-1) inhibitor, exhibiting 700-fold selectivity for COX-1 over COX-2.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves