Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
R0395
Rapamycin
Rapamycin from Streptomyces hygroscopicus
from Streptomyces hygroscopicus, ≥95% (HPLC), powder, mTOR inhibitor
Sinonimo/i:
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, Sirolimus
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
1 MG
372,00 €
Scegli un formato
Cambia visualizzazione
1 MG
372,00 €
About This Item
Formula empirica (notazione di Hill):
C51H79NO13
Numero CAS:
Peso molecolare:
914.17
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Rapamycin from Streptomyces hygroscopicus, ≥95% (HPLC), powder
Livello qualitativo
Saggio
≥95% (HPLC)
Stato
powder
Colore
off-white
Solubilità
ethanol: 2 mM
DMSO: soluble
Spettro attività antibiotica
fungi
yeast
Modalità d’azione
enzyme | inhibits
protein synthesis | interferes
Temperatura di conservazione
−20°C
Stringa SMILE
CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC
InChI
1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Informazioni sul gene
human ... FKBP1A(2280)
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Categorie correlate
Descrizione generale
Chemical structure: macrolide
Rapamycin is derived from Streptomyces hygroscopicus . It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.[1] It suppresses protein kinase C activity and enhances ion transport in A6 cells. It also suppresses the immune response in membrane and cytosolic preparations.[2] Additionally, it has specific effects on the translation of endogenous mRNAs and inhibits the translation of 5′TOP mRNAs by blocking p70s6k activation in the signaling pathway. Rapamycin exhibits antineoplastic properties.
Applicazioni
Rapamycin from Streptomyces hygroscopicus has been used:
- to treat BV2 cells or BV2-LC3 cells for autophagy assay[3]
- as an autophagy activator in the bone marrow mesenchymal stem cells (BM-MSCs) transfected with lentivirus carrier of small interfering RNA for FOXO3 (siFOXO3) to study the effects of Forkhead Box O3 (FOXO3) on the autophagy of BM-MSCs[4]
- to pre-incubate villi to inhibit the mammalian target of rapamycin complex 1 (mTORC1) signaling[5]
Azioni biochim/fisiol
A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
Caratteristiche e vantaggi
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Altre note
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Carc. 2 - Repr. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Scegli una delle versioni più recenti:
Certificati d'analisi (COA)
Lot/Batch Number
Non trovi la versione di tuo interesse?
Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells
Rokaw MD, et al.
The Journal of Biological Chemistry, 271, 32468-32473 (1996)
FOXO3 is targeted by miR-223-3p and promotes osteogenic differentiation of bone marrow mesenchymal stem cells by enhancing autophagy
Long C, et al.
Human Cell : Official Journal of Human Cell Research Society (2021)
Activation of autophagy pathway suppresses the expression of iNOS, IL6 and cell death of LPS-stimulated microglia cells
Han HE, et al.
Biomolecules & Therapeutics, 21, 21-21 (2013)
Rapamycin for longevity: opinion article
Blagosklonny, Mikhail V
Aging (Albany. NY.), 11, 8048-8048 (2019)
Line Heylen et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(10), 1505-1511 (2015-02-15)
Transplant recipients are at risk for invasive aspergillosis (IA), associated with a significant mortality rate. Renal transplant-specific risk factors have not been established. Forty-one adult kidney transplant recipients diagnosed with proven or probable IA from 1995 through 2013 were identified
Articoli
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
-
What is the Department of Transportation shipping information for this product?
1 risposta-
Utile?
-
-
What are the extinction coefficient values for Product R0395, Rapamycin, solutions?
1 risposta-
The E1% extinction coefficient values in 95% ethanol at 267 nm, 277 nm and 288 nm have been reported and are listed in the product information sheet (under Documents, above).
Utile?
-
-
What is the solubility of Product R0395, Rapamycin?
1 risposta-
Rapamycin is soluble in DMSO and in methanol (each at 25 mg/mL) and in ethanol (2 mM). It is insoluble in water. Additional solubility information is in the product information sheet (under Documents, above).
Utile?
-
-
How should we store solutions of Product R0395, Rapamycin?
1 risposta-
Rokaw, M.D. et al. J. Biol. Chem. 271, 32468 (1996) described storage of a 2 mM solution of rapamycin in ethanol at -70 °C which was diluted into serum-free media before use. Unless otherwise noted for other solvents, it may be best to prepare solutions fresh and protected from light. Please refer to our product information sheet at our website.
Utile?
-
-
What is the shelf life of Product R0395, Rapamycin, as received?
1 risposta-
The product has a recommended retest date of 2 years but the actual recommended retest date for each lot is on the Certificate of Analysis. We guarantee the quality of the product through this date for unopened bottles stored at -20 °C.
Utile?
-
Filtri attivi
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
