553211
Rapamycin
≥95% (HPLC), solution, mTOR inhibitor, Calbiochem
Sinonimo/i:
InSolution Rapamycin, mTOR Inhibitor I
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About This Item
Formula empirica (notazione di Hill):
C51H79NO13
Peso molecolare:
914.17
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
product name
Rapamycin, InSolution, ≥98%, 5 mM, inhibits mTOR and blocks activation of p70 S6 Kinase
Livello qualitativo
Saggio
≥95% (HPLC)
Forma fisica
solution
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
desiccated (hygroscopic)
protect from light
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Descrizione generale
Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
Azioni biochim/fisiol
Cell permeable: no
Primary Target
Mammalian target of rapamycin (mTOR)
Mammalian target of rapamycin (mTOR)
Product does not compete with ATP.
Reversible: no
Target IC50: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Irritant (B)
Stato fisico
A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
Ricostituzione
Following initial use, aliquot and freeze (-20°C).
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Punto d’infiammabilità (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificati d'analisi (COA)
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