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P4374

Sigma-Aldrich

Phthalocyanine tetrasulfonate hydrate

solid

Sinonimo/i:

29H,29H,31H-Phthalocyanine-C,C,C,C-tetrasulfonic acid, PcTS, Phthalocyanine tetrasulfonic acid, Tetrasulfophthalocyanine

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About This Item

Formula empirica (notazione di Hill):
C32H18N8O12S4 · xH2O
Numero CAS:
1173097-70-5
Peso molecolare:
834.79 (anhydrous basis)
Numero MDL:
MFCD08276972
Codice UNSPSC:
12352200
ID PubChem:
24724578

Stato

solid

Livello qualitativo

100

Condizioni di stoccaggio

protect from light

Colore

dark blue

Temperatura di conservazione

2-8°C

Stringa SMILE

[H]O[H].OS(=O)(=O)c1ccc2c3nc(nc4[nH]c(nc5nc(nc6[nH]c(n3)c7cc(ccc67)S(O)(=O)=O)c8cc(ccc58)S(O)(=O)=O)c9cc(ccc49)S(O)(=O)=O)c2c1

InChI

1S/C32H18N8O12S4.H2O/c41-53(42,43)13-1-5-17-21(9-13)29-33-25(17)37-30-22-10-14(54(44,45)46)2-6-18(22)27(34-30)39-32-24-12-16(56(50,51)52)4-8-20(24)28(36-32)40-31-23-11-15(55(47,48)49)3-7-19(23)26(35-31)38-29;/h1-12H,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H2,33,34,35,36,37,38,39,40);1H2
QNPPZKALMXYKPI-UHFFFAOYSA-N

Applicazioni

Phthalocyanine tetrasulfonate hydrate has been used as a tau aggregation inhibitor (TAI) to study its effects on Tau secretion in neuroblastoma cells. It has also been used as an anionic phthalocyanine to study its effects on telomere G-quadruplex stabilization.

Azioni biochim/fisiol

Inhibitor of protein aggregation, including α-synuclein, and the formation of protease-resistant prion protein.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
080M4719
125K4710

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Iron(II) phthalocyanine Dye content ~90 %

Sigma-Aldrich

379549

Iron(II) phthalocyanine

Zinc phthalocyanine Dye content 97 %

Sigma-Aldrich

341169

Zinc phthalocyanine

Ciaran K McLoughlin et al.
Sensors (Basel, Switzerland), 20(18) (2020-09-16)
Fluorescein, and derivatives of fluorescein, are often used as fluorescent probes and sensors. In systems where pH is a variable, protonation/deprotonation of the molecule can influence the pertinent photophysics. Fluorination of the xanthene moiety can alter the molecule's pKa such
Maria Merezhko et al.
Cell reports, 25(8), 2027-2035 (2018-11-22)
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that appear to spread throughout the brain via a cell-to-cell transmission process that includes secretion and uptake of pathological Tau, followed by templated misfolding of normal Tau in recipient cells.
Chang-yue Chen et al.
Journal of the American Chemical Society, 133(38), 15036-15044 (2011-08-19)
Inhibition of telomerase activity through stabilizing telomere G-quadruplex with small chemical ligands is emerging as a novel strategy for cancer therapy. For the large number of ligands that have been reported to inhibit telomerase activity, it is difficult to validate
Takao Ohtomo et al.
Journal of analytical methods in chemistry, 2012, 520248-520248 (2012-05-09)
The chemiluminescence (CL) signal immediately appeared when a hydrogen peroxide solution was injected into an iron-phthalocyanine tetrasulfonic acid (Fe-PTS) aqueous solution. Moreover, the CL intensity of Fe-PTS decreased by adding l-tyrosine. Based on these results, the determination of trace amounts
Suzette A Priola et al.
The Journal of infectious diseases, 188(5), 699-705 (2003-08-23)
The transmissible spongiform encephalopathy (TSE) diseases are rare, neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans. There are no effective treatments available for clinical use in humans. We now demonstrate that, in 2
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