P1431
Calmodulin from bovine testes
BioUltra, ≥98% (SDS-PAGE), lyophilized powder, essentially salt free
Sinonimo/i:
CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator
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0.2 MG
141,00 €
0.5 MG
227,00 €
1 MG
433,00 €
2 MG
741,00 €
Scegli un formato
Cambia visualizzazione
0.2 MG
141,00 €
0.5 MG
227,00 €
1 MG
433,00 €
2 MG
741,00 €
About This Item
Prodotti consigliati
Origine biologica
bovine testis
Livello qualitativo
Nome Commerciale
BioUltra
Saggio
≥98% (SDS-PAGE)
Stato
lyophilized powder
PM
16.79 kDa
Condizioni di stoccaggio
(Keep container tightly closed in a dry and well-ventilated place)
tecniche
ligand binding assay: suitable
Impurezze
salt, essentially free
N° accesso UniProt
applicazioni
cell analysis
Temperatura di conservazione
−20°C
Informazioni sul gene
cow ... CALM3(520277)
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Categorie correlate
Descrizione generale
Applicazioni
Calmodulin from bovine testes has been used:
- as a component of the reaction mixture in PhosphoSens assay to measure Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) substrate phosphorylation[3]
- to generate standard curve for the determination of in situ calmodulin concentration in tissues[4]
- as a ligand in radio-ligand binding for studying calmodulin affinity[5]
Azioni biochim/fisiol
Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.
Calmodulin (CaM) aids in the Ca2+ signal transduction pathway in higher plants and animals. Ca2+ binding is required for CaM activation. Upon activation, CaM binds and activates numerous target proteins involved in a variety of cellular processes including regulation of plant metabolism, phytohormone signaling, ion transport, protein folding, protein phosphorylation and dephosphorylation[1], cell motility, exocytosis, and cytoskeletal assembly. In neurons, calcium-activated CaM helps in the regulation of glutamate receptors, modulation of proteins in signaling pathways, and regulation of voltage-gated calcium channels (VGCCs) activity.[2]
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Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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I clienti hanno visto anche
The diversity of calcium sensor proteins in the regulation of neuronal function
McCue HV, et al.
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Nane Griem-Krey et al.
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Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a potential target for acute neuroprotection due to its key role in physiological and pathological glutamate signaling. The hub domain organizes the CaMKII holoenzyme into large oligomers, and additional functional effects on holoenzyme
E J McConnell et al.
Circulation research, 86(2), 191-197 (2000-02-10)
Plasma membrane (Ca(2+)+Mg(2+))-ATPase and Ca(2+) transport activities, best characterized in human erythrocytes, are stimulated by calmodulin and thought to play a crucial role in the termination of cellular Ca(2+) signaling in all cells. In plasma membranes isolated from cultured porcine
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