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Merck
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Documenti fondamentali

O9387

Sigma-Aldrich

Oxatomide

≥99%

Sinonimo/i:

1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one

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10 MG
290,50 €

290,50 €

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10 MG
290,50 €

About This Item

Formula empirica (notazione di Hill):
C27H30N4O
Numero CAS:
60607-34-3
Peso molecolare:
426.55
Numero CE:
262-320-9
Numero MDL:
MFCD00211147
Codice UNSPSC:
51111800
ID PubChem:
24278615
NACRES:
NA.77

290,50 €

Prezzo di listino415,00 €Risparmia il 30%
Per informazioni sulla disponibilità, contatta il Servizio Clienti.

Saggio

≥99%

Stato

powder

Colore

white

Solubilità

DMSO: soluble
ethanol: soluble

Ideatore

Johnson & Johnson

Stringa SMILE

O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5

InChI

1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
BAINIUMDFURPJM-UHFFFAOYSA-N

Informazioni sul gene

human ... DRD3(1814)

Descrizione generale

Oxatomide, a histamine H1-receptor antagonist,[1] is bound at high levels to plasma proteins in human blood.[2]

Azioni biochim/fisiol

Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.
Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines.[2] Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma[1] and vulvar lichen sclerosus.[3]

Caratteristiche e vantaggi

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCT6989
MKCT8869
MKCR1623
MKCR7151
MKCP1201

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H Kimata
European journal of clinical investigation, 33(6), 513-517 (2003-06-11)
Playing video games causes physical and psychological stress, including increased heart rate and blood pressure and aggression-related feelings. Use of mobile phones is very popular in Japan, and frequent ringing is a common and intrusive part of Japanese life. Atopic
Hiroyuki Mizuguchi et al.
Pharmaceutics, 12(6) (2020-06-12)
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity. Bilastine is a non-sedative
Mariko Domae et al.
The Journal of allergy and clinical immunology, 111(3), 567-572 (2003-03-19)
Eosinophils accumulated in sites of allergic inflammation are thought to play a crucial role in the pathogenesis of allergic disorders including asthma, allergic rhinitis, and atopic dermatitis, and tissue eosinophilia is attributable to increased eosinophil survival or decreased eosinophil apoptosis.
M Pandeeswaran et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 65(5), 1148-1153 (2006-02-21)
The charge transfer complex (CT-complex) between oxatomide drug and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) was studied spectrophotometrically in 10 solvents at different temperatures. The donor oxatomide is found to form stable 1:1 stoichiometric complex with DDQ and the stoichiometry was unaffected by change
G Marone et al.
Journal of investigational allergology & clinical immunology, 9(4), 207-214 (1999-10-08)
There is increasing evidence that histamine may have wider proinflammatory and immunomodulatory activities than previously reported. It may influence several functions of lymphocytes, monocytes, basophils and macrophages, modulating the release of inflammatory mediators and cytokines. These observations have aroused interest
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Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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