M6824

gamma-Mangostin

≥98% (HPLC)

• Sinonimo/i: 1,3,6,7-Tetrahydroxy-2,8-bis(3,3-dimethylallyl)xanthone, Demethylmangostin, Normangostin
• Formula empirica (notazione di Hill): C₂₃H₂₄O₆
• Numero CAS: 31271-07-5
• Peso molecolare: 396.43
• Numero MDL: MFCD00951752
• Codice UNSPSC: 12352200
• NACRES: NA.25

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: off-white to yellow
• Solubilità: methanol: 1 mg/mL, colorless to yellow
• applicazioni: metabolomics; vitamins, nutraceuticals, and natural products
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC1=CC(OC2=CC(O)=C(CC=C(C)C)C(O)=C2C3=O)=C3C(CC=C(C)C)=C1O
• InChI: 1S/C23H24O6/c1-11(2)5-7-13-15(24)9-18-20(22(13)27)23(28)19-14(8-6-12(3)4)21(26)16(25)10-17(19)29-18/h5-6,9-10,24-27H,7-8H2,1-4H3; VEZXFTKZUMARDU-UHFFFAOYSA-N

Descrizione

Descrizione generale

The fruit hulls of mangosteen contain three major bioactive compounds namely, α-, β-, and γ-mangostin.[1]

Applicazioni

γ-Mangostin has been used to study its inhibitory effect on Transthyretin (TTR) fibrillization, a homotetrameric protein involved in human hereditary amyloidosis.[2]

Azioni biochim/fisiol

The xanthone derivatives, namely α-, β-, and γ-mangostin have various biological activities including antiproliferative and anti-inflammatory activity, enhancement of natural killer (NK) cell activity, and antiviral effect against human immunodeficiency virus (HIV). γ-Mangostin is also reported to inhibit cyclooxygenase (COX-2) activity and NO production, which in turn reduces the level of prostaglandin E2. It is found to induce cell death in human colon cancer cells.[1]

Xanthone derivative isolated from the mangosteen hull (Garcinia mangostana). Exhibits antioxidant and anticancer properties. Mangosteen xanthones inhibit inflammation in human adipocytes which is important in understanding obesity-associated inflammation and the development of insulin resistance.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P301 + P312 + P330
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable