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O4375

Sigma-Aldrich

Oxytocin

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

Sinonimo/i:

α-Hypophamine, Oxytocic hormone

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250 I.U.
20,40 €
1000 I.U.
62,20 €

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250 I.U.
20,40 €
1000 I.U.
62,20 €

About This Item

Formula empirica (notazione di Hill):
C43H66N12O12S2
Numero CAS:
50-56-6
Peso molecolare:
1007.19
Beilstein:
3586108
Numero MDL:
MFCD00076731
Codice UNSPSC:
51111800
ID PubChem:
24897994
NACRES:
NA.32

20,40 €

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Origine biologica

synthetic

Sterilità

non-sterile

Stato

lyophilized powder

Attività specifica

~15 IU/mg solid (Prepared from synthetic oxytocin)

Solubilità

water: 10 mg/mL, clear, colorless

N° accesso UniProt

P01178
P30559
P70536

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

Stringa SMILE

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
XNOPRXBHLZRZKH-DSZYJQQASA-N

Informazioni sul gene

human ... OXT(5020) , OXTR(5021)
rat ... Oxtr(25342)

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Categorie correlate

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

Descrizione generale

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13.[1][2] It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.[1]

Applicazioni

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.[3]

Azioni biochim/fisiol

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation.[1] OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation.[2] Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity.[4] OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings.[5] Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).[6]
Stimulates uterine contraction and lactation; increases Na+ excretion; stimulates myometrial GTPase and phospholipase C.

Stato fisico

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000257585
0000272430
0000272429
0000257584
103H05241V

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Mia E Persson et al.
Hormones and behavior, 95, 85-93 (2017-08-03)
The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor
Margaret M Njoroge et al.
The American journal of tropical medicine and hygiene (2020-12-31)
Intranasal instillation of SE36, a malaria vaccine candidate antigen, in lactating BALB/c female mice resulted in the appearance of the antigen in breast milk as demonstrated by sandwich ELISA and Western blot. Pups born of immunologically naive mice and breastfed
Lack of plasminogen leads to milk stasis and premature mammary gland involution during lactation
Green KA
Developmental Biology, 299(1), 164-175 (2006)
Nitrergic modulation of vasopressin, oxytocin and atrial natriuretic peptide secretion in response to sodium intake and hypertonic blood volume expansion.
Ventura RR
Brazilian journal of medical and biological research, 35(9), 1101-1109 (2002)
The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization.
Rao VV
Cytogenetics and Cell Genetics, 61(4), 271-273 (1992)
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Domande

  1. I was wondering how many times Oxytocin lyophilized powder can be stored once it is diluted.

    1 risposta

    1. The stability of Oxytocin concentrates stored at various temperatures for 48 months was evaluated regularly for biological activity on rat uteri. It was found that concentrates kept in a refrigerator showed no loss of oxytocin activity, while samples kept at 21°C showed a slight loss of activity (about 1.5% per year), and those at 30°C showed a marked loss of activity (about 10% per year). Similar results were obtained with dilute injections of oxytocin. The study concluded that oxytocin in solution has a shelf life of 3 years at 21°C but should not be exposed to higher temperatures (Nachtmann et al. 1981).

      In a simulation study conducted by WHO in collaboration with IDA Foundation, two batches of three brands of oxytocin ampoules were stored at different temperatures and samples were assayed for oxytocin content over a period of 2 years (Hogerzeil et al. 1993). Based on the results (Figure 2), WHO and IDA suggested the following guidelines for the shelf life of oxytocin injections at higher temperatures:

      - At 2°C- 8°C, shelf life of 3 years.
      - Below 21°C, shelf life of 2 years.
      - At 25°C, the shelf life is reduced to 1 year.
      - At 30°C, the shelf life is reduced to 6 months.
      - At 40°C transport maximum 1 week.

      Utile?

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