N4267

Neurokinin A

≥97% (HPLC)

• Sinonimo/i: α-Neurokinin, Neuromedin L, Substance K
• Formula condensata: C₅₀H₇₉N₁₃O₁₅S
• Numero CAS: 86933-74-6
• Peso molecolare: 1133.32
• Numero MDL: MFCD00167560
• Codice UNSPSC: 51111800
• ID PubChem: 24897700
• NACRES: NA.32

Proprietà

• Livello qualitativo: 200
• Saggio: ≥97% (HPLC)
• Stato: powder
• Composizione: Peptide content, ≥70%
• N° accesso UniProt: P20366
• Temperatura di conservazione: −20°C
• Stringa SMILE: CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)Cc2cnc[nH]2)C(C)O)C(C)C)C(N)=O
• InChI: 1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69); HEAUFJZALFKPBA-UHFFFAOYSA-N
• Informazioni sul gene: human ... TAC1(6863)

Descrizione

Amino Acid Sequence

His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2

Descrizione generale

Neurokinin A is an 11 amino acid peptide. It is a member of tachykinin family, which includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1. The gene encoding neurokinin A is localized on human chromosome 7q21.3.[1][2]

Azioni biochim/fisiol

Neurokinin A improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro.[3] It participates in the movement of several organ tracts, triggers glandular secretion and controls autonomic reflexes. Neurokinin A plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.[1]

Altre note

Lyophilized from 0.1% TFA in H2O

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)