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M8759

Sigma-Aldrich

3-Maleimidobenzoic acid N-hydroxysuccinimide ester

Sinonimo/i:

MBS

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About This Item

Formula empirica (notazione di Hill):
C15H10N2O6
Numero CAS:
58626-38-3
Peso molecolare:
314.25
Beilstein:
1505254
Numero CE:
261-368-8
Numero MDL:
MFCD00005514
Codice UNSPSC:
47101511
ID PubChem:
24897286

Punto di fusione

175-177 °C (lit.)

Solubilità

ethyl acetate or DMF: ≤20 mg/mL (may require addition of solvent to coupling buffer to at least 5% to maintain solubility)

Temperatura di conservazione

−20°C

Stringa SMILE

O=C1CCC(N1OC(C2=CC=CC(N3C(C=CC3=O)=O)=C2)=O)=O

InChI

1S/C15H10N2O6/c18-11-4-5-12(19)16(11)10-3-1-2-9(8-10)15(22)23-17-13(20)6-7-14(17)21/h1-5,8H,6-7H2
LLXVXPPXELIDGQ-UHFFFAOYSA-N

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Applicazioni

Heterobifunctional crosslinking reagent reactive toward primary amine and sulfhydryl. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.0, followed by coupling to compounds containing sulfhydryl by thioether at same pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.

Altre note

The aryl maleimide is less stable than alkyl maleimide linkers.

Sostituito da

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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H H Keah et al.
The journal of peptide research : official journal of the American Peptide Society, 57(1), 1-10 (2001-02-13)
The synthesis of peptides containing 0, 1 and 2 cysteine residues related to the human sperm tail protein, tpx-1, is described. These synthetic peptides, following conjugation to keyhole limpet hemocyanin modified with maleimidobenzoic acid N-hydroxysuccinimide ester, were used as immunogens
T Arata
Journal of biochemistry, 109(2), 335-340 (1991-02-01)
Polymerization of G-actin in the presence of salt and phalloidin was blocked by treatment of G-actin with m-maleimidobenzoic acid N-hydroxysuccinimide ester (MBS) (designated as m-actin). The actin dimer produced by chemical crosslinking of F-actin with N,N'-p-phenylenedimaleimide did not polymerize and
Huan Xie et al.
Analytical chemistry, 75(21), 5797-5805 (2003-11-01)
Protocols for modifying gold nanoparticles with peptide-bovine serum albumin (BSA) conjugates are described within. The resulting constructs were characterized using a number of techniques including static fluorescence spectroscopy and time-correlated single photon counting spectroscopy (TCSPC) in order to quantify peptide-BSA
D A Collings et al.
Planta, 212(3), 392-403 (2001-04-06)
The distribution of actin filaments within the gravity-sensing columella cells of plant roots remains poorly understood, with studies over numerous years providing inconsistent descriptions of actin organization in these cells. This uncertainty in actin organization, and thus in actin's role
H R Mortensen et al.
Dysphagia, 30(3), 304-314 (2015-02-19)
Many head and neck cancer (HNC) survivors experience reduced quality of life due to radiotherapy (RT)-related dysphagia. The aim of this prospective randomized trial was to evaluate the impact of prophylactic swallowing exercises on swallowing-related outcomes in HNC patients treated
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