M4890
β2-Microglobulin from human urine
≥98% (SDS-PAGE), lyophilized powder
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Il prodotto M4890 al momento non è in vendita nel tuo paese Contatta l'Assistenza Tecnica.
Prodotti consigliati
Origine biologica
human urine
Livello qualitativo
Saggio
≥98% (SDS-PAGE)
Stato
lyophilized powder
PM
11.6 kDa
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... B2M(567)
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Applicazioni
Azioni biochim/fisiol
β2 microglobulin (β2-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. The interaction is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide antigens in CD8+ cells. A transient complex of MHC heavy chain and β2-M is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β2-M complex to the cell surface. Absence of binding leads to degradation in the proteasome.
Confezionamento
Package size based on protein content.
Nota sulla preparazione
Prepared by the method of Berggard and Bearn.
Esclusione di responsabilità
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
M Weller et al.
Acta neurologica Scandinavica, 86(2), 129-133 (1992-08-01)
Cerebrospinal fluid (CSF) and serum samples of 20 patients with central nervous system manifestations of hematological malignancies including primary cerebral lymphoma (n = 5) and disseminated non-Hodgkin lymphoma (n = 7) were examined for albumin, IgG, IgM, fibronectin, beta 2-microglobulin
Yusuke Kambe et al.
Journal of controlled release : official journal of the Controlled Release Society, 327, 8-18 (2020-08-04)
Metabolic pathways in the body are highly specific. Dysfunction of a metabolic pathway triggers the accumulation of its target substance. For example, kidney failure results in increased β2-microglobulin blood levels, causing dialysis-related amyloidosis. Previously, we proposed a novel therapeutic concept
Yusuke Kambe et al.
Biomaterials science, 9(16), 5551-5558 (2021-07-08)
Kidney dysfunction increases the blood levels of β2-microglobulin (β2-m), triggering dialysis-related amyloidosis. Previously, we developed a navigator molecule, consisting of a fusion protein of the N-terminal domain of apolipoprotein E (ApoE NTD) and the α3 domain of the major histocompatibility
K Imai et al.
British journal of cancer, 104(2), 300-307 (2010-12-24)
Identification of tumour-associated antigens (TAAs) that induce cytotoxic T lymphocytes (CTLs) specific to cancer cells is critical for the development of anticancer immunotherapy. In this study, we aimed at identifying a novel TAA of pancreatic cancer for immunotherapy. On the
E Pamer et al.
Annual review of immunology, 16, 323-358 (1998-05-23)
Classical class I molecules assemble in the endoplasmic reticulum (ER) with peptides mostly generated from cytosolic proteins by the proteasome. The activity of the proteasome can be modulated by a variety of accessory protein complexes. A subset of the proteasome
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
