M1071

Anti-Mucolipin-3 (C-terminal)

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-MCOLN3, Anti-MLN3, Anti-TRPML3
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen ~75 kDa
• Reattività contro le specie: rat, mouse, human
• Confezionamento: antibody small pack of 25 μL
• Convalida avanzata: recombinant expression; Learn more about Antibody Enhanced Validation
• Concentrazione: ~1.5 mg/mL
• tecniche: western blot: 0.5-1 μg/mL using HEK-293T cells expressing human mucolipin-3
• N° accesso UniProt: Q8TDD5
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... MCOLN3(55283) ; mouse ... Mcoln3(171166) ; rat ... Mcoln3(308022)

Descrizione

Descrizione generale

Mucolipin-3 (MLN3) belongs to mucolipin subfamily. It consists of six transmembrane domain (TMD), with a putative pore region between TMD5 and TMD6 and cytosolic N- and C-termini. MLN3 is a Ca²⁺ permeable cation channel, which is expressed in the plasma membrane, endosomes, lysosomes and autophagosomes.

Specificità

Additional bands may be observed at ~150 kDa and ~50 kDa due to aggregation and degradation, respectively.

Immunogeno

synthetic peptide corresponding to amino acids 529-542 of human mucolipin-3. This sequence is identical in mouse and rat mucoplipin-3.

Applicazioni

Anti-Mucolipin-3 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Azioni biochim/fisiol

Mucolipin-3 (MLN3) regulates endocytic pathway and lysosomal integrity. It modulates membrane trafficking and autophagy. Abnormalities of transient receptor potential cation channel, mucolipin subfamily, member 3 (TRPML3) are linked to early deafness, pigmentation abnormalities, and perinatal lethality in mice. Mutations in mouse mucolipin-3 encoded by the MCOLN3 gene, are associated with deafness and pigmentation defects in varitint-waddler mice.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)