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L7393

Sigma-Aldrich

Leu-Leu methyl ester hydrobromide

≥97% (TLC)

Sinonimo/i:

LLME, HBr, Leu-Leu-Ome, HBr

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About This Item

Formula empirica (notazione di Hill):
C13H26N2O3 · HBr
Numero CAS:
16689-14-8
Peso molecolare:
339.27
Numero MDL:
MFCD00216855
Codice UNSPSC:
12352209
ID PubChem:
24896476
NACRES:
NA.26

product name

Leu-Leu methyl ester hydrobromide, ≥97% (TLC)

Saggio

≥97% (TLC)

Forma fisica

powder

Colore

white

Temperatura di conservazione

−20°C

Stringa SMILE

Br.COC(=O)C(CC(C)C)NC(=O)C(N)CC(C)C

InChI

1S/C13H26N2O3.BrH/c1-8(2)6-10(14)12(16)15-11(7-9(3)4)13(17)18-5;/h8-11H,6-7,14H2,1-5H3,(H,15,16);1H
QIPBCIHWFATZOF-UHFFFAOYSA-N

Applicazioni


  • VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.: The article discusses the maintenance of lysosomal function and transcription factor activity in muscle cells, which may be influenced by small molecular agents like Leu-Leu methyl ester hydrobromide that affect cellular processes (Arhzaouy et al., 2019).

Azioni biochim/fisiol

Leu-Leu methyl ester (LLME, Leu-Leu-OMe) may be used to induce protease-dependent cell death (apoptosis) in immune cells such as mast cells, phagocytes, monocytes/macrophages and natural killer cells.
Peptide toxic to natural killer T cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sodio cloruro BioXtra, ≥99.5% (AT)

Sigma-Aldrich

S7653

Sodio cloruro

Chrisovalantis Papadopoulos et al.
The EMBO journal, 36(2), 135-150 (2016-11-01)
Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates
M Odaka et al.
Photochemistry and photobiology, 63(6), 800-806 (1996-06-01)
L-Leucyl-L-leucine methyl ester (Leu-Leu-OMe), an apoptosis inducer in natural killer cells and macrophages, was caged with trans-o-hydroxycinnamoyl (3a-d), trans-o-mercaptocinnamoyl (4) and o-nitrobenzyl derivatives (5a, b), and the photochemical reactivity of these derivatives in phosphate-buffered saline containing 1% dimethyl sulfoxide and
F R Melo et al.
Scandinavian journal of immunology, 74(4), 354-362 (2011-06-08)
Mast cells (MC) have pathogenic roles in numerous disorders, and strategies that stabilize MC or induce MC apoptosis are therefore emerging as possible therapeutic regimens. A typical feature of MC is their high content of secretory lysosomes (granules), containing numerous
A Poloni et al.
Leukemia, 20(2), 329-335 (2005-12-13)
The engraftment ability of mesenchymal cells was investigated in 26 patients receiving allogeneic transplantation from HLA-identical siblings with reduced-intensity conditioning (RIC). The stem cell source was bone marrow (BM) in eight patients and G-CSF-mobilized peripheral blood hematopoietic cells in 18
Catherina H Bird et al.
Biological chemistry, 391(8), 999-1004 (2010-06-12)
Reporter proteins comprising granzyme B (GrB) fused to eGFP, ecliptic pHluorin or mCherry, were generated and used to study granule (lysosome) distribution and properties in COS-1 cells and natural killer cells. The reporters resembled native GrB in biosynthesis and localization
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