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L2023

Sigma-Aldrich

Leupeptin trifluoroacetate salt

powder, ≥90% (HPLC)

Sinonimo/i:

Acetyl-Leu-Leu-Arg-al trifluoroacetate salt

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1 MG
56,80 €
5 MG
178,00 €
10 MG
201,00 €
25 MG
365,00 €
50 MG
639,00 €

56,80 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Tutte le immagini(1)

Scegli un formato

Cambia visualizzazione
1 MG
56,80 €
5 MG
178,00 €
10 MG
201,00 €
25 MG
365,00 €
50 MG
639,00 €

About This Item

Formula empirica (notazione di Hill):
C20H38N6O4 · xC2HF3O2
Numero CAS:
147385-61-3
Peso molecolare:
426.55 (free base basis)
Numero MDL:
MFCD00133458
Codice UNSPSC:
12352202
ID PubChem:
329817397
NACRES:
NA.77

56,80 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

Nome del prodotto

Leupeptin trifluoroacetate salt, ≥90% (HPLC), microbial

Origine biologica

microbial

Livello qualitativo

200

Saggio

≥90% (HPLC)

Stato

powder

Solubilità

H2O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 °C.)

Temperatura di conservazione

−20°C

Stringa SMILE

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1
WUHGBZVQELGOMH-FRKSIBALSA-N

Azioni biochim/fisiol

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Risultati analitici

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000395822
0000374433
0000325073
0000325072
0000374433

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