I9154
Interleukin-10 from rat
>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Sinonimo/i:
IL-10
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25 μG
506,00 €
5 μG
282,50 €
506,00 €
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Cambia visualizzazione
25 μG
506,00 €
5 μG
282,50 €
About This Item
506,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Origine biologica
rat
Livello qualitativo
Ricombinante
expressed in E. coli
Saggio
>95% (SDS-PAGE)
Stato
lyophilized powder
Potenza
1-35 ng/mL ED50
PM
predicted mol wt ~19 kDa
Confezionamento
pkg of 5 μg
Impurezze
endotoxin, tested
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
rat ... Il10(25325)
Applicazioni
Interleukin-10 (IL-10) from rat has been used to study the anti-allodynic effect of IL-10 in rat model.[1]
Azioni biochim/fisiol
Interleukin-10 is an important regulator of the functions of lymphoid and myeloid cells. IL-10 can block the activation of cytokine synthesis and several accessory functions of macrophages. Human and mouse IL-10 share a 73% sequence homology. However, human IL-10 acts on both human and mouse target cells, while mouse IL-10 has species-specific activity. In mouse, the cellular sources of IL-10 consist of Th2 cells, activated fetal thymocytes, macrophages, keratinocytes, LY-1+ (CD5+), and normal B cells. In human, the cellular sources of IL-10 consist of CD4+ T cells and T cell clones, thymocytes, B cells, B cell lymphomas, macrophages, mast cell lines and keratinocytes. IL-10 stimulates the growth of stem cells, mast cells and thymocytes. IL-10 enhances cytotoxic T cell development, and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing the cell-type dependent expression of either angiogenic or angiostatic factors.
Interleukin-10 regulates lymphoid and myeloid cell functions. It blocks the activation of cytokine synthesis and several accessory functions of macrophages. IL-10 enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion. IL-10 regulates angiogenesis by inducing cell-type dependent expression of either angiogenic or angiostatic factors.
Interleukin-10 regulates lymphoid and myeloid cell functions; blocks the activation of cytokine synthesis and several accessory functions of macrophages; enhances cytotoxic T cell development and co-stimulates B cell differentiation and Ig secretion.
Stato fisico
Lyophilized from a 0.2 μm filtered in 20 mM Tris, 0.1 M sodium chloride containing 50 μg of bovine serum albumin per 1 μg of cytokine.
Risultati analitici
The biological activity is measured in a cell proliferation assay using the murine mast cell line, MC/9.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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Byung-Sang Lee et al.
Journal of Korean medical science, 28(2), 308-314 (2013-02-13)
We examined the possible anti-inflammatory mechanisms of gabapentin in the attenuation of neuropathic pain and the interaction between the anti-allodynic effects of gabapentin and interleukin-10 (IL-10) expression in a rat model of neuropathic pain. The anti-allodynic effect of intrathecal gabapentin
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Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing
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Immunity to malaria can be acquired but only after repeat exposures to polymorphic Plasmodium. However, the development of clinical outcomes during P. falciparum infection is not clearly understood. This study elucidated whether monocytes, neutrophils and pro/anti-inflammatory cytokines were associated with
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