I4770
Anti-Interleukin-9 antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Sinonimo/i:
Anti-IL-9
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Origine biologica
goat
Coniugato
unconjugated
Forma dell’anticorpo
IgG fraction of antiserum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
lyophilized powder
Reattività contro le specie
human
tecniche
neutralization: suitable
N° accesso UniProt
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... IL9(3578)
Descrizione generale
Interleukin-9 (IL-9) is a pleotropic cytokine produced by activated T cells and also by mast cells in response to LPS and IL-1. The production of IL-9 is amplified by TGF-β, IL-2 and IL-25. The biological effects of IL-9 are mediated by IL-9 receptor (IL-9R) that is made up of an α and a γ chain. IL-9 signalling results in the activation of major signalling pathways involving STAT1, -3 and -5, MAPK, PI3K and IRS. IL-9 is a pro-inflammatory cytokine and promotes allergic inflammation and airway remodelling in lungs. It also is important in cell growth and differentiation of T cells, B cells, mast cells, hematopoietic progenitors, epithelial cells and airway smooth muscle cells
Monoclonal Anti-Human Interleukin-9 recognizes human IL-9. It does not neutralize the activity of recombinant mouse IL-9. In ELISA and immunoblotting, it shows 20% cross reactivity with mouse IL-9.
Monoclonal Anti-Human Interleukin-9 recognizes human IL-9. It does not neutralize the activity of recombinant mouse IL-9. In ELISA and immunoblotting, it shows 20% cross reactivity with mouse IL-9.
Specificità
The antibody neutralizes the biological activity of recombinant human IL-9, but not recombinant mouse IL-9.
Immunogeno
recombinant human IL-9 expressed in Sf 21 insect cells.
Applicazioni
Anti-Interleukin-9 antibody may be used for immunoblotting at a working concentration of 1.0 μg/ml. For ELISA a concentration of 0.5 μg/ml is recommended. The antibody is also suitable for neutralization reactions.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Nota sulla preparazione
Purified using protein G.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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Ulla-Angela Temann et al.
The Journal of clinical investigation, 109(1), 29-39 (2002-01-10)
IL-9 is a pleiotropic cytokine with multiple functions on many cell types involved in the pathology of human asthma. The constitutive overexpression of IL-9 in the lungs of transgenic mice resulted in an asthma-like phenotype. To define the contribution of
Jennifer Kearley et al.
American journal of respiratory and critical care medicine, 183(7), 865-875 (2010-10-26)
IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting
Ritobrata Goswami et al.
Journal of immunology (Baltimore, Md. : 1950), 186(6), 3283-3288 (2011-03-04)
IL-9 was first described in the late 1980s as a member of a growing number of cytokines that had pleiotropic functions in the immune system. Although many biological functions have been attributed to IL-9, it remains an understudied cytokine. A
J C Renauld et al.
Journal of leukocyte biology, 57(3), 353-360 (1995-03-01)
Interleukin-9 (IL-9) is a multifunctional cytokine produced by activated TH2 clones in vitro and during TH2-like T cell responses in vivo. The IL-9 receptor is a member of the hemopoietin receptor superfamily and interacts with the gamma chain of the
J H Bauer et al.
The Journal of biological chemistry, 273(15), 9255-9260 (1998-05-16)
Interleukin-9 (IL-9) is a cytokine with pleiotropic effects on mast cell and T cell lines. It exerts its effects through the IL-9R complex consisting of IL-9Ralpha and the common gammac subunit. Here we report functional evidence for receptor heteromerization for
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