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I3901

Sigma-Aldrich

IL-1α rat

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

Interleukin-1α, Lymphocyte activating factor, rIL-1α, IL-1α

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About This Item

Numero MDL:
MFCD01635091
Codice UNSPSC:
12352202
NACRES:
NA.77

Nome del prodotto

Interleukin-1α from rat, IL-1α, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Origine biologica

rat

Livello qualitativo

100

Ricombinante

expressed in E. coli

Saggio

≥97% (SDS-PAGE)

Stato

lyophilized powder

Potenza

1-10 pg/mL ED50

Qualità

endotoxin tested

PM

~18 kDa

Confezionamento

pkg of 5 μg

tecniche

cell culture | mammalian: suitable

Impurezze

≤0.1 EU/μg

N° accesso UniProt

P16598

Temperatura di conservazione

−20°C

Informazioni sul gene

rat ... Il1a(24493)

Categorie correlate

Azioni biochim/fisiol

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LA F), activates T cells and lymphocytes, which then proliferate and secrete Interleukin-2 (IL-2). The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.

Stato fisico

Lyophilized from 0.2 μm filtered phosphate buffered saline containing 0.25 mg of bovine serum albumin.

Risultati analitici

The biological activity of recombinant rat IL-1α was measured by its ability to stimulate cell proliferation using a mouse helper T cell line, D10.G4.1.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCV5886
MKCW2214
MKCW5204
MKCT5275
MKCR0785

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Xuankang Wang et al.
Frontiers in neuroscience, 15, 768262-768262 (2021-11-20)
After spinal cord injury (SCI), reactive astrocytes can be classified into two distinctive phenotypes according to their different functions: neurotoxic (A1) astrocytes and neuroprotective (A2) astrocytes. Our previous studies proved that photobiomodulation (PBM) can promote motor function recovery and improve
Xuankang Wang et al.
Journal of neuroinflammation, 18(1), 256-256 (2021-11-07)
Neurotoxic microglia and astrocytes begin to activate and participate in pathological processes after spinal cord injury (SCI), subsequently causing severe secondary damage and affecting tissue repair. We have previously reported that photobiomodulation (PBM) can promote functional recovery by reducing neuroinflammation
T Nishida et al.
Journal of biochemistry, 105(3), 351-357 (1989-03-01)
A cDNA sequence coding for rat interleukin-1 alpha (IL-1 alpha) has been isolated from a cDNA library that was prepared with mRNA derived from LPS-stimulated rat peritoneal macrophages by using human IL-1 alpha cDNA as a probe. The rat cDNA
Sualyneth Galarza et al.
Advanced healthcare materials, 9(4), e1901419-e1901419 (2020-01-17)
Bioengineers have designed numerous instructive brain extracellular matrix (ECM) environments with tailored and tunable protein compositions and biomechanical properties in vitro to study astrocyte reactivity during trauma and inflammation. However, a major limitation of both protein-based and synthetic model microenvironments
Shuqi Jiang et al.
Journal of inflammation research, 14, 5919-5937 (2021-11-23)
Astrocyte A1/A2 phenotypes may play differential role in the pathogenesis of periventricular white matter (PWM) damage in septic postnatal rats. This study aimed to determine whether melatonin (MEL) would improve the axonal hypomyelination through shifting A1 astrocytes towards A2. One-day-old
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Articoli

Interleukin Family (IL)

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

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