I2286

Irbesartan

≥98% (HPLC), powder

• Sinonimo/i: 2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, Avapro, BMS-186295, SR-47436
• Formula empirica (notazione di Hill): C₂₅H₂₈N₆O
• Numero CAS: 138402-11-6
• Peso molecolare: 428.53
• Numero MDL: MFCD00864464
• Codice UNSPSC: 12352200
• ID PubChem: 329815365
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to off-white
• Solubilità: DMSO: >25 mg/mL
• Ideatore: Bristol-Myers Squibb; Sanofi Aventis
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5
• InChI: 1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30); YOSHYTLCDANDAN-UHFFFAOYSA-N
• Informazioni sul gene: human ... AGTR1(185)

Descrizione

Descrizione generale

Irbesartan comprises bipentyl-tetrazole side chain. It is an imidazole derivative with high bioavailability and is metabolized by the enzyme cytochrome P450 2C9 isoenzyme in liver to be majorly eliminated by oxidation and glucuronidation.[1]

Applicazioni

Irbesartan has been used as an angiotensin II receptor type 1 (ATR1) blocker in carotid atheroma tissue.[2][3][4] It may be used to test its effect on allergic asthma in rat and mice mast cells.[5]

Azioni biochim/fisiol

Irbesartan is an angiotensin II type 1 (AT1) receptor antagonist with antihypertensive activity.[1] It also elicits selective peroxisome proliferator-activated receptor γ (PPARγ)-modulating activity and possesses anti-inflammatory properties.[1] Irbesartan shows protective cardiovascular effects[1] and provides protection against chronic glomerulonephritis.[5]

Caratteristiche e vantaggi

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb and Sanofi Aventis. To browse the list of other pharma-developed compounds, Approved Drugs, and Drug Candidates, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable