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H9633

Sigma-Aldrich

L-Homocysteic acid

≥98% (TLC)

Sinonimo/i:

L-2-Amino-4-sulfobutyric acid

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About This Item

Formula empirica (notazione di Hill):
C4H9NO5S
Numero CAS:
14857-77-3
Peso molecolare:
183.18
Numero MDL:
MFCD00066018
Codice UNSPSC:
12352106
ID PubChem:
24895863
NACRES:
NA.32

product name

L-Homocysteic acid, ≥95%

Saggio

≥95%
≥98% (TLC)

Forma fisica

powder

Colore

white to off-white

applicazioni

cell analysis

Stringa SMILE

N[C@@H](CCS(O)(=O)=O)C(O)=O

InChI

1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1
VBOQYPQEPHKASR-VKHMYHEASA-N

Applicazioni

L-Homocysteic acid has been used to study hydrogen peroxide-mediated changes in physiological and pathological conditions in the nervous system.

Azioni biochim/fisiol

L-Homocysteic acid (L-HCA) is an endogenous neurotransmitter ligand of NMDA (N-methyl-D-aspartate) receptors. It is an analog of glutamate and competitively suppresses glutamate-cystine (xc-) antiporter function in neurons, causing decrease in cysteine uptake.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Seleno-DL-cystine powder

Sigma-Aldrich

S1650

Seleno-DL-cystine

Selenomethionine United States Pharmacopeia (USP) Reference Standard

USP

1611955

Selenomethionine

3-Amino-1-propanesulfonic acid 97%

Sigma-Aldrich

A76109

3-Amino-1-propanesulfonic acid

DL-Homocysteine thiolactone hydrochloride ≥99.0% (AT)

Sigma-Aldrich

53530

DL-Homocysteine thiolactone hydrochloride

Seleno-L-cystine 95%

Sigma-Aldrich

545996

Seleno-L-cystine

Emina from bovine, ≥90%

Sigma-Aldrich

H9039

Emina

S-(5′-Adenosyl)-L-homocysteine crystalline

Sigma-Aldrich

A9384

S-(5′-Adenosyl)-L-homocysteine

L-cisteina ≥97%, FG

Sigma-Aldrich

W326305

L-cisteina

R Gurke et al.
Journal of pharmaceutical and biomedical analysis, 174, 578-587 (2019-07-02)
The role of homocysteic acid (HCA) in severe diseases like Alzheimer's disease is under discussion and some recent studies correlate elevated HCA concentrations with the diagnosis of Alzheimer's. However, non-selective and insufficiently sensitive methods have been used to quantitate HCA
T Knöpfel et al.
Neuroscience letters, 81(1-2), 188-192 (1987-10-16)
The effects of ionophoretically applied L-homocysteate (L-HCA), L-glutamate (L-Glu) and N-methyl-D-aspartate (NMDA) were compared in rat neocortical neurons recorded intracellularly in vitro. The firing pattern and the time course of membrane depolarization induced by L-HCA resembled those of NMDA responses.
Itopa E Ajayi et al.
Respiratory physiology & neurobiology, 252-253, 18-27 (2018-03-20)
Changes in cardiorespiratory control accompany the expression of complex emotions, indicative of limbic brain inputs onto bulbar autonomic pathways. Previous studies have focussed on the role of the prefrontal cortex in autonomic regulation. However, the role of the hippocampus, also
Danté T Johnson et al.
The Journal of biological chemistry, 294(32), 11969-11979 (2019-07-03)
Fast photochemical oxidation of proteins (FPOP) is a MS-based method that has proved useful in studies of protein structures, interactions, conformations, and protein folding. The success of this method relies on the irreversible labeling of solvent-exposed amino acid side chains
J W Olney et al.
Brain research bulletin, 19(5), 597-602 (1987-11-01)
L-Homocysteic acid (L-HCA) has been proposed as a natural transmitter at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor based on recent evidence that L-HCA occurs L-HCA occurs naturally in the mammalian CNS, is released from K+ stimulated brain
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