H8909
HBcAg core human
~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli
Sinonimo/i:
Hepatitis B virus core antigen
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100 μG
459,00 €
459,00 €
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Cambia visualizzazione
100 μG
459,00 €
About This Item
459,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Ricombinante
expressed in E. coli
Livello qualitativo
Saggio
≥95% (SDS-PAGE)
PM
18 kDa
Concentrazione
~1 mg/mL
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
hepatitis B virus ... HBVgp4(944568)
human ... HBVgp4(944568)
Descrizione generale
amino acids 1-183 of HBV core antigen.
Azioni biochim/fisiol
HBcAg core human is a capsid protein of hepatitis B virus (HBV). It acts as a viral factor for HBV clearance. HBcAg is implicated in viral replication.[1]
Hepatitis B virus core antigen (HBcAg) is a positive control for human HBV antibodies.In humans with chronic HBV (hepatitis B virus) infection, cytotoxic effects of blood T lymphocytes can be suppressed by incubating cells with antibodies against hepatitis B core antigen (HBcAg).[2] The antigen can also work as a T-cell independent antigen in athymic mice. However, it is an efficient immunogen, resulting in T-cell activation and increased anti-HBc levels.[3] High cytoplasmic/membranous expression of HBcAg is associated with increased liver inflammation.[4]
Stato fisico
Solution in 50% glycerol, 7.5 mM phosphate buffer, pH 7.2, 75 mM NaCl.
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Jun Hong et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 38(4), 362-373 (2007-11-21)
This study was undertaken to investigate whether plasmacytoid dendritic cells (PDC) are involved in the generation of a higher proportion of CD4(+) and CD25(+) regulatory T (Treg) cells in chronic hepatitis B virus (HBV) infection compared with healthy patients. The
Hepatitis B virus nucleocapsid but not free core antigen controls viral clearance in mice
Lin YJ, et al.
Journal of Virology, 86(17), 9266-9273 (2012)
M Mondelli et al.
Journal of immunology (Baltimore, Md. : 1950), 129(6), 2773-2778 (1982-12-01)
Peripheral blood T lymphocytes from 21 patients with chronic HBV infection were incubated with autologous hepatocytes in a microcytotoxicity assay. Cytotoxicity was significantly increased in 13 cases, and in 12 of these the cytotoxic effect of the T lymphocytes was
J B Kurtz et al.
Journal of virological methods, 96(2), 127-132 (2001-07-11)
A measurable serological response to hepatitis C infection is delayed on average until 70 days after infection. In addition, it may not occur in some immunocompromised people. Detection of free hepatitis C (HCV) core antigen in blood has enabled diagnosis
Long Liu et al.
Journal of medical virology (2020-02-23)
Hepatitis B virus (HBV) chronically infects approximately 350 million people worldwide, and 600 000 deaths are caused by HBV-related hepatic failure. Golgi protein 73 (GP73) is a serum biomarker for liver diseases, including chronic hepatitis B. Here, we determine the effect
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