F8304

Flavoxate hydrochloride

≥98% (HPLC), solid

• Sinonimo/i: 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride, DW-61, Rec-7-0040
• Formula empirica (notazione di Hill): C₂₄H₂₅NO₄ · HCl
• Numero CAS: 3717-88-2
• Peso molecolare: 427.92
• Numero CE: 223-066-4
• Numero MDL: MFCD00072099
• Codice UNSPSC: 12352200
• ID PubChem: 24724484
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Colore: white
• Solubilità: H₂O: ~6.6 mg/mL
• Ideatore: Johnson & Johnson
• Stringa SMILE: Cl[H].CC1=C(Oc2c(cccc2C1=O)C(=O)OCCN3CCCCC3)c4ccccc4
• InChI: 1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H; XOEVKNFZUQEERE-UHFFFAOYSA-N
• Informazioni sul gene: human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622)

Descrizione

Azioni biochim/fisiol

Flavoxate, a flavone derivative and a tertiary-amine antimuscarinic possess antispasmodic properties. It is a strong smooth muscle relaxant that selectively acts on the pelvic region and is used in the symptomatic treatment of overactive bladder (OAB) and incontinence. Post-absorption in the gastrointestinal tract, flavoxate is localized in bladder, liver, and kidney tissues. It mediates the inhibition of phosphodiesterase (PDE) in the urinary bladder. Use of flavoxate aids pain relief in inflammatory disorders of the urinary tract.

L-type Ca²⁺ (Ca_v1.2) channel inhibitor

Caratteristiche e vantaggi

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H335
• Consigli di prudenza: P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312
• Classi di pericolo: Acute Tox. 4 Oral - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves