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D7910

Sigma-Aldrich

3,4-Dichloroisocoumarin

serine protease inhibitor

Sinonimo/i:

3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one

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About This Item

Formula empirica (notazione di Hill):
C9H4Cl2O2
Numero CAS:
51050-59-0
Peso molecolare:
215.03
Beilstein:
6802625
Numero MDL:
MFCD00036960
Codice UNSPSC:
12352202
ID PubChem:
24278386
NACRES:
NA.77

Livello qualitativo

200

Saggio

≥98% (TLC)

Stato

powder

Solubilità

ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

Temperatura di conservazione

2-8°C

Stringa SMILE

ClC1=C(Cl)c2ccccc2C(=O)O1

InChI

1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
SUGXUUGGLDCZKB-UHFFFAOYSA-N

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Applicazioni

Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors.

Altre note

Effective concentration 5-100 μM.

Quantità

Half-life = 20 min at pH 7.5.

Substrati

Serine protease inhibitor. Active towards a wide range of serine proteases including granzymes. Not active toward β-lactamases.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H315,H319,H335

Classi di pericolo

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000301459
0000301459
0000249571
0000249570
0000249576

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Diego López León et al.
iScience, 23(3), 100932-100932 (2020-03-11)
Pathogenic bacteria secrete virulence factors that interact with the human host to establish infections. The human immune system evolved multiple mechanisms to fight bacterial invaders, including immune proteases that were demonstrated to contribute crucially to antibacterial defense. Here we show
Premkumari Kumarathasan et al.
Particle and fibre toxicology, 15(1), 34-34 (2018-08-12)
There is a paucity of mechanistic information that is central to the understanding of the adverse health effects of source emission exposures. To identify source emission-related effects, blood and saliva samples from healthy volunteers who spent five days near a
Anežka Tichá et al.
Cell chemical biology, 24(12), 1523-1536 (2017-11-07)
Rhomboid-family intramembrane proteases regulate important biological processes and have been associated with malaria, cancer, and Parkinson's disease. However, due to the lack of potent, selective, and pharmacologically compliant inhibitors, the wide therapeutic potential of rhomboids is currently untapped. Here, we
Brett M Babin et al.
Cell chemical biology, 29(5), 897-909 (2021-10-03)
The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis of the mycobacterial cell envelope.
K S Lang et al.
Cell death and differentiation, 11(2), 231-243 (2003-11-15)
Erythrocytes lack nuclei and mitochondria, the organelles important for apoptosis of nucleated cells. However, following increase of cytosolic Ca(2+) activity, erythrocytes undergo cell shrinkage, cell membrane blebbing and breakdown of phosphatidylserine asymmetry, all features typical for apoptosis in nucleated cells.
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