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Sigma-Aldrich

α-Cyano-4-hydroxycinnamic acid

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

Sinonimo/i:

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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54,00 €
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10 G
54,00 €
25 G
120,00 €

About This Item

Formula condensata:
HOC6H4CH=C(CN)CO2H
Numero CAS:
Peso molecolare:
189.17
Beilstein:
3271427
Numero CE:
Numero MDL:
Codice UNSPSC:
12352106
ID PubChem:
NACRES:
NA.77

54,00 €


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Nome del prodotto

α-Cyano-4-hydroxycinnamic acid, ≥98% (TLC), powder

Saggio

≥98% (TLC)

Stato

powder

Colore

yellow

Punto di fusione

245-250 °C (lit.)

Solubilità

H2O: slightly soluble
methanol: water: soluble
polar organic solvents: soluble

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
AFVLVVWMAFSXCK-VMPITWQZSA-N

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Applicazioni

α-Cyano-4-hydroxycinnamic acid has been used to block monocarboxylate transporters.[1][2]
α-Cyano-4-hydroxycinnamic acid is a useful hydrophobic matrix solution for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.[3] Antibiotics, peptide nucleic acids (a new class of DNA mimics), and proteins with masses as high as 66,000 Da have been successfully analyzed by using this as a matrix solution.

Azioni biochim/fisiol

α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport.[4][5][6] It is also reported to block β-cell apical anion exchange (IC50 of 2.4 mM).[7]

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Skin Sens. 1B

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


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Domande

1–2 di 2 domande  
  1. What is the Department of Transportation shipping information for this product?

    1 risposta
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Utile?

  2. What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?

    1 risposta
    1. α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.

      Utile?

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