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B5399

Sigma-Aldrich

(±)-Baclofen

≥98% (HPLC), solid

Sinonimo/i:

(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal

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About This Item

Formula empirica (notazione di Hill):
C10H12ClNO2
Numero CAS:
1134-47-0
Peso molecolare:
213.66
Numero CE:
214-486-9
Numero MDL:
MFCD00055143
Codice UNSPSC:
12352200
ID PubChem:
24278146
NACRES:
NA.32

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

white to very faintly yellow

Solubilità

1 M HCl: 50 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

ClC1=CC=C(C(CN)CC(O)=O)C=C1

InChI

1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
KPYSYYIEGFHWSV-UHFFFAOYSA-N

Informazioni sul gene

human ... GABBR1(2550) , GABBR2(9568)
rat ... Gabbr1(81657) , Gabra2(29706)

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Applicazioni

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABAB receptor agonist:
  • as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
  • to test its effects on in vivo motor function tests and performance of mutant mice
  • to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
  • to test its effect in reducing dendritic excitability in Purkinje neurons

Azioni biochim/fisiol

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABAB) agonist, baclofen may be involved in the potentiation of dendritic potassium K+ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).
GABAB receptor agonist; skeletal muscle relaxant; antispastic agent.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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vibrant-m

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Sigma-Aldrich

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Bromperidol European Pharmacopoeia (EP) Reference Standard

B1152000

Bromperidol

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Behavioural brain research, 290, 77-83 (2015-05-03)
Our prior work demonstrated the involvement of the caudal granular subregion of the insular cortex in a rat model of nicotine self-administration. Recent studies in various animal models of addiction for nicotine and other drugs have identified a role for
The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective.
de Beaurepaire, et al.
Frontiers in Psychiatry, 9, 708-708 (2021)
The effects of baclofen for the treatment of gastroesophageal reflux disease: a meta-analysis of randomized controlled trials.
Li, et al.
Gastroenterology Research and Practice, 2014, 307805-307805 (2020)
Andrés P Varani et al.
Psychopharmacology, 231(15), 3031-3040 (2014-02-21)
Nicotine is a major active ingredient in tobacco and plays a major role in tobacco addiction. In rodents, repeated nicotine administration produces behavioral responses related to its addictive properties, such as reinforcing effects and physical dependence. The aim of the
Di Liu et al.
Pain, 159(1), 175-175 (2017-10-28)
Increasing evidence suggests that the mesolimbic reward system plays critical roles in the regulation of depression and nociception; however, its circuitry and cellular mechanisms remain unclear. In this study, we investigated the output-specific regulatory roles of dopaminergic (DA) neurons within
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