A9210
Annexin V FITC Conjugate from human placenta
Sinonimo/i:
Annexin V, Calphosbindin I, Lipocortin V, PAP-1
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10 μG
816,00 €
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Cambia visualizzazione
10 μG
816,00 €
About This Item
Codice UNSPSC:
41106305
NACRES:
NA.32
Prodotti consigliati
Stato
buffered aqueous solution
Livello qualitativo
Grado di funzionalizzazione
1-2 mol FITC per mol annexin V
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
2-8°C
Informazioni sul gene
human ... ANXA5(308)
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Applicazioni
For detection of apoptotic cells by flow cytometry or fluorescence microscopy.
Azioni biochim/fisiol
Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium.
Annexins are ubiquitous homologous proteins that bind phospholipids in the presence of calcium. The cellular changes involved in the apoptotic process include loss of phospholipid asymmetry during the early stages. This phenomenon is universal and is not limited to stimulus or to mammalian cells, but also occurs in insect and plant cells. In living cells, phosphatidylserine is transported to the inside of the lipid bilayer by the Mg2+ATP dependent enzyme, aminophospholipid translocase. At the onset of apoptosis, phosphatidylserine becomes translocated to the external surface of the cell membrane. Since the movement of phosphatidylserine from the internal membrane surface to the external surface is an early indicator of apoptosis, annexin V and its conjugates that interact strongly and specifically with phosphatidylserine may be used to detect apoptosis. Annexin V conjugates can be used to detect apoptotic cells significantly earlier than DNA-based assays. Fluorescent dye labeled annexin V have applications in flow cytometry, fluorescence microscopy, and laser scanning cytometry.
Confezionamento
Package size based on protein content
Stato fisico
Solution in 50 mM Tris-HCl, pH 7.5, containing 100 mM NaCl.
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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