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Merck
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Documenti

A5656

Sigma-Aldrich

(±)-Anabasine

≥90% (TLC), liquid

Sinonimo/i:

3-(2-Piperidinyl)pyridine, Neonicotine

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About This Item

Formula empirica (notazione di Hill):
C10H14N2
Numero CAS:
13078-04-1
Peso molecolare:
162.23
Numero MDL:
MFCD00006370
Codice UNSPSC:
12352100
ID PubChem:
24891007

Saggio

≥90% (TLC)

Forma fisica

liquid

Attività ottica

[α]25/D 0°, c = 1 in H2O(lit.)

Colore

colorless to yellow

Temp. transizione

freezing point 9 °C

Solubilità

H2O: 10 mg/mL
ethanol: 50 mg/mL

Densità

1.05 g/mL at 25 °C (lit.)

applicazioni

agriculture
environmental

Stringa SMILE

C1CCC(NC1)c2cccnc2

InChI

1S/C10H14N2/c1-2-7-12-10(5-1)9-4-3-6-11-8-9/h3-4,6,8,10,12H,1-2,5,7H2
MTXSIJUGVMTTMU-UHFFFAOYSA-N

Informazioni sul gene

mouse ... Chrna7(11441) , Chrnb1(11443)

Azioni biochim/fisiol

Tobacco alkaloid; potent nicotinic acetylcholine receptor agonist.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

199.4 °F - closed cup

Punto d’infiammabilità (°C)

93 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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W R Kem et al.
The Journal of pharmacology and experimental therapeutics, 283(3), 979-992 (1998-02-12)
We assessed the pharmacological activity of anabaseine, a toxin found in certain animal venoms, relative to nicotine and anabasine on a variety of vertebrate nicotinic receptors, using cultured cells, the Xenopus oocyte expression system, contractility assays with skeletal and smooth
M J Parker et al.
Molecular pharmacology, 54(6), 1132-1139 (1998-12-18)
We used equilibrium binding analysis to characterize the agonist binding properties of six different rat neuronal nicotinic receptor subunit combinations expressed in Xenopus laevis oocytes. The alpha4beta2 receptor bound [3H]cytisine with a Kdapp of 0.74 +/- 0. 14 nM. The
P M Gocze et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 13(4), 266-272 (1999-10-26)
To reveal the well known effect of smoking on the incidence of early abortion, the possible effects of cigarette alkaloids on progesterone and estradiol synthesis were investigated. A suspected cause for early spontaneous abortion is corpus luteum insufficiency. The present
N Mizrachi et al.
Journal of forensic sciences, 45(3), 736-741 (2000-06-16)
Death of a worker occurred after ingestion of unknown amounts of Nicotiana glauca G leaves. The leaves were cooked after having been mistakenly considered to be spices of a type which grow in Thailand. After ingestion, two Thai workers collapsed
Y Lu et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1127-1134 (1999-11-24)
Several neurochemical and electrophysiological studies have shown that neuronal nicotinic receptors are desensitized by pretreatment with lower agonist concentrations than are required to activate the receptors, but the extent of desensitization and agonist concentration required to produce desensitization vary depending
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