424M-1

CITED1 (5H6) Mouse Monoclonal Antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: ascites fluid
• Tipo di anticorpo: primary antibodies
• Clone: 5H6, monoclonal
• Descrizione: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• Stato: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (424M-14); vial of 0.5 mL concentrate (424M-15); bottle of 1.0 mL predilute (424M-17); vial of 1.0 mL concentrate (424M-16); bottle of 7.0 mL predilute (424M-18)
• Produttore/marchio commerciale: Cell Marque^®
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• Isotipo: IgG2aκ
• Controllo: Wilms’ tumor
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: nuclear
• Informazioni sul gene: human ... CITED1(4435)

Descrizione

Descrizione generale

CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.^1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.³ Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.¹ CITED1 expression has been shown to persist in blastemal cell populations of human WT.^1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.^1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.¹ CITED1 has been detected in 86.8% of WT Cases.²

Qualità

IVD

IVD

IVD

RUO

Linkage

CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

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Altre note

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Note legali

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany