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Merck
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Documenti fondamentali

348M-9

Sigma-Aldrich

WT1 (6F-H2) Mouse Monoclonal Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41
Prezzi e disponibilità al momento non sono disponibili

Origine biologica

mouse

Livello qualitativo

100
500

Coniugato

unconjugated

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

6F-H2, monoclonal

Descrizione

For In Vitro Diagnostic Use in Select Regions (See Chart)

Stato

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

vial of 0.1 mL concentrate (348M-94)
vial of 0.5 mL concentrate (348M-95)
bottle of 1.0 mL predilute (348M-97)
vial of 1.0 mL concentrate (348M-96)
bottle of 7.0 mL predilute (348M-98)

Produttore/marchio commerciale

Cell Marque®

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotipo

IgG1κ

Controllo

kidney, mesothelioma, ovarian carcinoma (serous), testis

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Visualizzazione

nuclear

Informazioni sul gene

human ... WT1(7490)

Categorie correlate

Descrizione generale

Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed intissues of mesodermal origin. The Wilms’ tumor gene encodes a protein that functionsas a tumor suppressor gene mapped to human chromosome 11p13.2 Nuclear WT1immunoreactivity has been observed in high frequencies in several types of mesoderm-derived tumors including epithelioid mesothelioma and ovarian serous carcinoma and thus isused as a marker for these neoplasms.

Qualità


IVD
IVD
IVD
RUO

Linkage

WT-1 Positive Control Slides, Product No. 348S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: [email protected]

Note legali

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificati d'analisi (COA)

Lot/Batch Number
0000424985
0000422329
0000425408
0000422329
0000425408

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Martin Köbel et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 35(5), 430-441 (2016-03-15)
There are 5 major histotypes of ovarian carcinomas. Diagnostic typing criteria have evolved over time, and past cohorts may be misclassified by current standards. Our objective was to reclassify the recently assembled Canadian Ovarian Experimental Unified Resource and the Alberta
Koji Tsuta et al.
Applied immunohistochemistry & molecular morphology : AIMM, 17(2), 126-130 (2009-06-12)
Malignant pleural mesothelioma (MPM) is known to mimic the morphology of a number of diverse neoplastic conditions. WT-1 protein is conventionally used as a positive mesothelioma marker. Recently, a new monoclonal antibody clone WT49 has recently become commercially available. To
Sarah K Galfione et al.
International journal of clinical and experimental pathology, 7(5), 2536-2543 (2014-06-27)
Vascular lesions are commonly encountered in routine pathologic practice and often pose diagnostic challenges owing to their morphologic diversity. Although WT-1 expression was reported in some vascular tumors, little is known about its staining patterns in a spectrum of vascular
M A Ghanem et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 6(11), 4265-4271 (2000-12-06)
Wilms' tumor is one of the most common solid tumors of children. The protein product of the tumor-suppressor gene, Wilms' tumor 1 (WT-1), binds to the same DNA sequences as the protein product of the early growth response 1 (EGR-1)
Rena J May et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(15 Pt 1), 4547-4555 (2007-08-03)
Wilms' tumor 1 protein (WT1), a transcription factor overexpressed in malignant mesothelioma, leukemias, and other solid tumors, is an ideal target for immunotherapy. WT1 class I peptide epitopes that were identified and shown to stimulate CD8(+) T cells are being
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