282200

Galangin

autophagy inducing flavonoid

• Sinonimo/i: 3,5,7-Trihydroxyflavone, Norizalpinin
• Formula empirica (notazione di Hill): C₁₅H₁₀O₅
• Numero CAS: 548-83-4
• Peso molecolare: 270.24
• Beilstein: 272179
• Numero CE: 208-960-4
• Numero MDL: MFCD00006833
• Codice UNSPSC: 41116107
• ID PubChem: 57648294
• NACRES: NA.79

Proprietà

• Saggio: ≥95% (HPLC)
• Stato: powder
• Colore: yellow
• Punto di fusione: 214-215 °C (lit.)
• Stringa SMILE: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H; VCCRNZQBSJXYJD-UHFFFAOYSA-N
• Informazioni sul gene: human ... ADORA2A(135) , ADORA3(140) , CYP1A2(1544) ; rat ... Adora1(29290) , Adora2a(25369)

Descrizione

Descrizione generale

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.[1]

Applicazioni

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity[1]
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes[2]
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy[3]

Azioni biochim/fisiol

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory[1] and anti-obesity properties.[4] In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis.[5] Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.[6]

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves