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P9672

Supelco

Probucol

analytical standard

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About This Item

Formula empirica (notazione di Hill):
C31H48O2S2
Numero CAS:
23288-49-5
Peso molecolare:
516.84
Numero CE:
245-560-9
Numero MDL:
MFCD00079281
Codice UNSPSC:
41116107
ID PubChem:
329820354
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

200

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C

InChI

1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
FYPMFJGVHOHGLL-UHFFFAOYSA-N

Informazioni sul gene

human ... ABCA1(19) , IL1B(3553) , IL6(3569) , TNF(7124)

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Categorie correlate

Descrizione generale

Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Azioni biochim/fisiol

Enhances selective uptake of HDL-associated cholesteryl esters.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
SLCR4304
SLCM2132
SLBS3412V
SLBR2496V
MKBQ8447V

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Chang-Jiang Ge et al.
Chinese medical journal, 125(14), 2472-2476 (2012-08-14)
The plasma cystatin C concentration (PcyC) has been demonstrated to have prognostic value in acute coronary syndrome, but the study of PcyC in patients with borderline coronary lesions is limited. Moreover, the effects of atorvastatin and probucol on PcyC and
Jonathan Watt et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(4), 698-708 (2012-05-15)
The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Current drugs and polymers used to coat coronary stents remain suboptimal in terms of
Eduardo Luiz Gasnhar Moreira et al.
Neuroscience letters, 541, 193-198 (2013-03-09)
Epidemiological studies indicate that high midlife plasma cholesterol levels increases the risk of Alzheimer's disease. Moreover, middle-aged familial hypercholesterolemia (FH) subjects show a particularly high incidence of mild cognitive impairments (MCI). These evidence points to hypercholesterolemia as one of the
Ryusuke Takechi et al.
Clinical and experimental pharmacology & physiology, 40(1), 45-52 (2012-11-22)
Dysfunction of the blood-brain barrier (BBB) is an early pathological feature of vascular dementia and Alzheimer's disease (AD) and is triggered by inflammatory stimuli. Probucol is a lipid-lowering agent with potent anti-oxidant properties once commonly used for the treatment of
Rong Wu et al.
Digestive diseases and sciences, 58(1), 163-171 (2012-08-11)
We sought to evaluate the effects of probucol on steatohepatitis and associated molecular mechanisms in a rat model of nonalcoholic steatohepatitis (NASH) induced by high-fat diet (HFD). Forty male rats weighing 100-120 g were randomly assigned to the following treatments (n = 10
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Articoli

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

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