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N9890

Supelco

Norfloxacin

analytical standard, ≥98% (TLC)

Sinonimo/i:

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid

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About This Item

Formula empirica (notazione di Hill):
C16H18FN3O3
Numero CAS:
70458-96-7
Peso molecolare:
319.33
Numero CE:
274-614-4
Numero MDL:
MFCD00079532
Codice UNSPSC:
41116107
ID PubChem:
329818696
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

200

agenzia

EPA 1694

Saggio

≥98% (TLC)

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

clinical testing

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

InChI

1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
OGJPXUAPXNRGGI-UHFFFAOYSA-N

Informazioni sul gene

human ... CYP1A2(1544)
rat ... Gabra1(29705)

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Descrizione generale

Chemical structure: fluoroquinolone
Norfloxacin is a broad spectrum antibiotic, which is used against a wide variety of gram positive and gram negative bacteria.

Applicazioni

Norfloxacin may be used as a standard in the determination of norfloxacin in human serum samples using fluorometric spectrophotometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Azioni biochim/fisiol

Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
Mode of action: inhibits bacterial DNA replication
Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000249279
0000227061
0000249280
SLCQ1196
0000185003

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Sigma-Aldrich

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Sigma-Aldrich

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Norfloxacin-d5 VETRANAL®, analytical standard

Supelco

34058

Norfloxacin-d5

Oxolinic acid quinolone antibiotic

Sigma-Aldrich

O0877

Oxolinic acid

Lomefloxacin hydrochloride

Sigma-Aldrich

L2906

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Ciprofloxacin VETRANAL®, analytical standard

Supelco

33434

Ciprofloxacin

Difloxacin hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0001423

Difloxacin hydrochloride

Pefloxacin

Sigma-Aldrich

P0106

Pefloxacin

L M Cavaco et al.
Journal of clinical microbiology, 47(9), 2751-2758 (2009-07-03)
Fluoroquinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of the topoisomerase genes. However, transferable genes encoding quinolone resistance have recently been described. The current methods for susceptibility testing are not
Fluorescence reaction and complexation equilibria between norfloxacin and aluminium (III) ion in chloride medium
Djurdjevic.TP, et al.
Analytica Chimica Acta, 300, 253-259 (1995)
Deepika Sharma et al.
European journal of medicinal chemistry, 44(6), 2347-2353 (2008-10-15)
In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against gram positive, gram negative and fungal species. The results of antibacterial study indicated that compounds 15
Anita Reinhardt et al.
Antimicrobial agents and chemotherapy, 51(4), 1341-1350 (2007-01-31)
Intubated patients frequently become colonized by Pseudomonas aeruginosa, which is subsequently responsible for ventilator-associated pneumonia. This pathogen readily acquires resistance against available antimicrobials. Depending on the resistance mechanism selected for, resistance might either be lost or persist after removal of
Kristine H Wammer et al.
Water research, 47(1), 439-448 (2012-11-13)
Fluoroquinolone (FQ) antibacterial compounds are frequently detected in the aquatic environment, and photodegradation is expected to play an important role in FQ fate in some sunlit surface waters. This study investigated the direct aquatic photochemistry of three FQs: norfloxacin, ofloxacin
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