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G6257

Sigma-Aldrich

Glutaraldeide

Grade II, 25% in H2O

Sinonimo/i:

Dialdeide glutarica, Pentano-1,5-diale

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10 ML
16,20 €
100 ML
57,70 €
10 X 10 ML
69,10 €
1 L
161,00 €

16,20 €

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Cambia visualizzazione
10 ML
16,20 €
100 ML
57,70 €
10 X 10 ML
69,10 €
1 L
161,00 €

About This Item

Formula condensata:
OHC(CH2)3CHO
Numero CAS:
111-30-8
Peso molecolare:
100.12
Beilstein:
605390
Numero MDL:
MFCD00007025
Codice UNSPSC:
12352114
ID PubChem:
24895250
NACRES:
NA.21

16,20 €

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Tipo

Grade II

Livello qualitativo

200

Stato

liquid

Concentrazione

25% in H2O

tecniche

electron microscopy: suitable

Colore

colorless

Intervallo di pH utile

2.9

Punto di fusione

-10  °C ((14 °F ))

Solubilità

water: soluble

applicazioni

cell analysis
sample preparation

Stringa SMILE

[H]C(CCCC([H])=O)=O

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
SXRSQZLOMIGNAQ-UHFFFAOYSA-N

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Descrizione generale

Glutaraldehyde, known as Glutaric dialdehyde or Pentane-1,5-dial, serves as a versatile reagent with applications spanning various research domains, including cell biology and biochemical research. It finds applications as a protein crosslinker, aids in enzyme immobilization for microscopy, and contributes to histochemistry and cytochemistry processes. As an amine-reactive homobifunctional crosslinker, it acts as a cell fixative before procedures like SDS-PAGE, staining, or electron microscopy, making it a valuable tool for diverse morphological studies.

Glutaraldehyde demonstrates efficacy in crosslinking amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it allows direct coupling of biotin hydrazides to nucleic acids, offering potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. Moreover, in histology studies, Glutaraldehyde is employed for preserving tissue sections and preparing them for detailed examination.

Applicazioni

Glutaraldehyde solution has been used:
  • for fixation of mouse[1] and esophageal cancer cell lines[2]
  • to crosslink amyloid-β protein[3]
  • to crosslink gelatin in 3D scaffold preparation of trachea[4]

Azioni biochim/fisiol

Glutaraldehyde is an effective protein crosslinker and finds application in techniques like enzyme immobilisation microscopy, histochemistry and cytochemistry. It exists in different forms under acidic or neutral conditions.[5] It is toxic to aquatic organisms.[6] Its allergic nature leads to hypersensitivity reactions. Contact of glutaraldehyde vapors in endoscopy contributes to Colitis.[7]

Caratteristiche e vantaggi

  • Versatile and adaptable for wide variety of research applications
  • Ready-made solution reduces the need for preparation time

Confezionamento

Not refrigerated en route

Avvertenza

This grade is not recommended for use as an electron microscopy fixative.

Nota sulla preparazione

Not specially purified.

Altre note

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Esclusione di responsabilità

“The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.”

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Avvertenze

Danger

Classi di pericolo

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Rischi supp

EUH071

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
MKCX3341
BCCK0578
BCCM7878
MKCW7739
BCCL3047

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Sigma-Aldrich

1.12179

Glutaraldeide

Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls
Esparza TJ, et al.
Annals of Neurology, 73(1), 104-119 (2013)
A novel tissue-engineered trachea with a mechanical behavior similar to native trachea
Park JH, et al.
Biomaterials, 62(1), 106-115 (2015)
Glutaraldehyde: behavior in aqueous solution, reaction with proteins, and application to enzyme crosslinking
Migneault I, et al.
Biotechniques, 37(5), 790-802 (2004)
Sorption characteristics of mixed molecules of glutaraldehyde from water on mesoporous acid-amine modified low-cost activated carbon: mechanism, isotherm, and kinetics
Lloyd M, et al.
Journal of Chemistry, 2015, 790-802 (2015)
Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin
Du XX, et al.
Biomedicine and Pharmacotherapy, 67(5), 417-424 (2013)
Visualizza tutti i documenti correlati

Domande

1–5 di 5 domande  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Utile?

  3. Is the 25% concentration in terms of w/w or w/v?

    1 risposta

    1. This product is a 25% weight per weight (w/w) solution.

      Utile?

  4. What type of product should be ordered to ensure that each lot provides clear glutaraldehyde solutions?

    1 risposta

    1. Grade II glutaraldehyde solutions may exhibit variation in color between lots. For consistent clarity, it is advisable to order Grade I glutaraldehyde, which is a purer product. This higher-grade variant must be stored frozen and is shipped with wet or dry ice. While Grade II is often suitable for industrial or technical applications, Grade I glutaraldehyde solutions are designed for more precise applications, such as electron microscopy, where a pure product is essential.

      Utile?

  5. What is the storage?

    1 risposta

    1. This product may be stored at ambient temperature. This material is air-sensitive and should be stored under inert gas to preserve product integrity.

      Utile?

Recensioni

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