A7085

Acetaminofene

BioXtra, ≥99.0%

• Sinonimo/i: 4′-idrossiacetanilide, 4-acetamidofenolo, N-(4-idrossifenil)acetammide, N-acetil-4-amminofenolo, APAP, Paracetamolo
• Formula condensata: CH₃CONHC₆H₄OH
• Numero CAS: 103-90-2
• Peso molecolare: 151.16
• Beilstein: 2208089
• Numero CE: 203-157-5
• Numero MDL: MFCD00002328
• Codice UNSPSC: 12352111
• ID PubChem: 24891173
• NACRES: NA.25

Proprietà

• Nome Commerciale: BioXtra
• Livello qualitativo: 200
• Saggio: ≥99.0%
• Forma fisica: powder
• Impurezze: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• Residuo alla calcinazione: ≤0.1%
• Punto di fusione: 168-172 °C (lit.)
• Solubilità: ethanol: 0.5 M, clear, colorless
• Anioni in tracce: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• Cationi in tracce: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• Stringa SMILE: CC(=O)Nc1ccc(O)cc1
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10); RZVAJINKPMORJF-UHFFFAOYSA-N
• Informazioni sul gene: human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

Descrizione

Descrizione generale

Acetaminophen or paracetamol is an analgesic and antipyretic. It is however a weak non opioid analgesic.

Applicazioni

Acetaminophen has been used:

• as an anti-inflammatory drug to test its effect in lipid peroxidation in marine mussels
• to test its effect on neurite outgrowth in gamma-aminobutyric acid-ergic and glutamatergic neurons
• as a hepatocellular injury inducing agent in mice

Analgesico.

Azioni biochim/fisiol

Acetaminophen or paracetamol is an inhibitor of prostaglandin synthesis. It is complexed with arachidonic acid in central nervous system resulting in the formation of N-arachidonoylphentolamine, which is essential for the activation of cannabinoid receptor. Acetaminophen is metabolized to toxic N-acetyl-p-benzoquinone imine. Paracetamol is prescribed for osteoarthritis pain and inhibits cyclooxygenase 1 and 2 activities. It is metabolized by the cytochrome P450 enzymes in liver and is implicated in liver toxicity.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 364.3 °F - Pensky-Martens closed cup
• Punto d’infiammabilità (°C): 184.6 °C - Pensky-Martens closed cup
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves