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917397

Sigma-Aldrich

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

Sinonimo/i:

Semi-flexible linker for PROTAC® development

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About This Item

Formula empirica (notazione di Hill):
C12H20Cl2N2
Numero CAS:
2244085-89-8
Peso molecolare:
263.21
Numero MDL:
MFCD29075589
Codice UNSPSC:
12352116
NACRES:
NA.22

Forma fisica

powder

Livello qualitativo

100

Impiego in reazioni chimiche

reagent type: linker

Gruppo funzionale

amine

Temperatura di conservazione

2-8°C

Stringa SMILE

NCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl

Applicazioni

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Altre note

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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