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Aphidicolin

analytical standard

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About This Item

Formula empirica (notazione di Hill):
C20H34O4
Numero CAS:
38966-21-1
Peso molecolare:
338.48
Numero MDL:
MFCD00083214
Codice UNSPSC:
85151701
ID PubChem:
329769740
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

Saggio

≥95% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

clinical testing

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]3C[C@@H]4C[C@]23CC[C@]4(O)CO

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
NOFOAYPPHIUXJR-APNQCZIXSA-N

Categorie correlate

Descrizione generale

Aphidicolin is a diterpenoid metabolite of the fungi, Cephalosporium aphidicola and Phoma betae. It is known to be an antiviral drug and inhibits the incorporation of thymidine into DNA of cultured human embryonic lung cells.

Applicazioni

Aphidicolin may be used as a reference standard in the determination of the analyte in plasma samples using gas chromatography coupled with mass spectrometry (GC-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
BCCM2381
BCCH8502
BCCJ3649
BCCF2170
BCCB1923

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Chemistry of Fungi (2008)
Aphidicolin: A specific inhibitor of DNA polymerases in the cytosol of rat liver.
Ohashi M, et al.
Biochemical and Biophysical Research Communications, 82(4), 1084-1090 (1978)
A gas chromatographic mass spectrometric assay for the determination of aphidicolin in plasma of cancer patients.
Journal of Pharmaceutical Sciences, 78(5), 399-401 (1989)
Devin Sok et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(49), 17624-17629 (2014-11-26)
Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored candidates for vaccine design and immunotherapy because of their great neutralization breadth and potency. However, methods of isolating bnAbs against this site have been limited by the
Julian H Elliott et al.
PLoS pathogens, 10(10), e1004473-e1004473 (2014-11-14)
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important in maintaining HIV latency and histone deacetylase inhibitors (HDACi) may reverse latency by activating HIV
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