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59924

Sigma-Aldrich

TWEEN® 80

tested according to Ph. Eur.

Sinonimo/i:

Monooleato di polietilenglicole sorbitano, Monooleato di poliossietilene sorbitano, POE (20) sorbitano monooleato, Polisorbato 80

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100 G
32,30 €
1 KG
127,00 €

32,30 €


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Cambia visualizzazione
100 G
32,30 €
1 KG
127,00 €

About This Item

Numero CAS:
Numero MDL:
Codice UNSPSC:
12161900
NACRES:
NA.21

32,30 €


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agenzia

USP/NF
tested according to Ph. Eur.

Livello qualitativo

Tensione di vapore

<1 mmHg ( 20 °C)

Descrizione

non-ionic

Stato

liquid

PM

average mol wt 79,000

Numero d'aggregazione

60

Indice di rifrazione

n20/D 1.472 (lit.)

CMC

0.012

Temp. transizione

cloud point 65 °C

Densità

1.064 g/mL at 25 °C (lit.)

HLB

15

applicazioni

pharmaceutical (small molecule)

Stringa SMILE

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
RGPBUVUVZKQNHD-MDZDMXLPSA-N

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Descrizione generale

Polysorbate 80 is a surfactant.[1] Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.[2]

Applicazioni

Polysorbate 80 has been used in drug (rapamycin) treatment[3][4] and to study the effect of rapamycin on osteolysis and tumor growth.[3] It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.[5]

Azioni biochim/fisiol

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.[2]

Note legali

TWEEN is a registered trademark of Croda International PLC

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves


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Certificati d'analisi (COA)

Lot/Batch Number

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Priya N O Kasimbeg et al.
Journal of pharmaceutical sciences, 108(1), 155-161 (2018-10-14)
Characterizing protein aggregates in the presence of silicone oil is a long standing challenge for the pharmaceutical industry. Silicone oil is often used as a lubricant in devices that deliver and store therapeutic protein products and has been linked to
Enhancing the antibacterial efficacy of isoeugenol by emulsion encapsulation
Nielsen CK, et al.
International Journal of Food Microbiology, 229, 7-14 (2016)
Yuan Li et al.
Frontiers in microbiology, 11, 1450-1450 (2020-07-17)
Radiation therapy is a cornerstone of modern management methods for malignancies but is accompanied by diverse side effects. In the present study, we showed that food additives such as polysorbate 80 (P80) exacerbate irradiation-induced gastrointestinal (GI) tract toxicity. A 16S
Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin
Abdelaziz DM, et al.
Breast Cancer Research and Treatment, 143(2), 227-237 (2014)
Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions
Coors EA, et al.
Annals of Allergy, Asthma & Immunology, 95(6), 593-599 (2005)

Domande

1–2 di 2 domande  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Utile?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

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