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38399

Sigma-Aldrich

Diisopropylfluorophosphate

≥97.0% (GC)

Sinonimo/i:

DFP, DIFP, Diisopropyl phosphorofluoridate, Phosphoric acid diisopropyl ester fluoride

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About This Item

Formula condensata:
[(CH3)2CHO]2POF
Numero CAS:
55-91-4
Peso molecolare:
184.15
Beilstein:
1723307
Numero CE:
200-247-6
Numero MDL:
MFCD00008873
Codice UNSPSC:
12352200
ID PubChem:
329755682

Tensione di vapore

0.58 mmHg ( 20 °C)

Saggio

≥97.0% (GC)

Indice di rifrazione

n20/D 1.385 (lit.)

P. eboll.

62 °C/9 mmHg (lit.)

Punto di fusione

−82 °C (lit.)

Densità

1.06 g/mL at 25 °C (lit.)

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)OP(F)(=O)OC(C)C

InChI

1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
MUCZHBLJLSDCSD-UHFFFAOYSA-N

Informazioni sul gene

human ... ACHE(43) , PTGS1(5742) , PTGS2(5743)

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Azioni biochim/fisiol

Potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase; also inhibits cathepsin G, cholinesterase, coagulation factor Xa, leucocyte elastase, pancreatic elastase, tissue kallikrein, plasmin, subtilisin, and thrombin. Inhibition of acetylcholinesterase makes this compound especially toxic. Inhibits apoptosis induced by ricin and bacterial toxins.

Risultati analitici

Typically used at a concentration of 0.10 mM. A safer alternative inhibitor for serine protease is phenylmethylsulfonyl fluoride (PMSF).

Altre note

Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases); Inhibition of carboxypeptidase but not DAP I

Sostituito da

N° Catalogo
Descrizione
Determinazione del prezzo

D0879

Diisopropylfluorophosphate

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330

Classi di pericolo

Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificati d'analisi (COA)

Lot/Batch Number
1404328
1364933
1352956
423829/1
419680/1

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J.K. McDonald et al.
Methods in Enzymology, XV(B), 275-275 (1972)
A molecular probe for the highly selective chromogenic detection of DFP, a mimic of Sarin and Soman nerve agents.
Raúl Gotor et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(43), 11994-11997 (2011-09-17)
Yonggang Li et al.
Toxicology and applied pharmacology, 262(2), 194-204 (2012-05-16)
Current medical countermeasures against organophosphate (OP) nerve agents are effective in reducing mortality, but do not sufficiently protect the CNS from delayed brain damage and persistent neurological symptoms. In this study, we examined the efficacy of neuregulin-1 (NRG-1) in protecting
J.A. Cohen et al.
Methods in Enzymology, XI, 686-686 (1967)
Marko S Todorovic et al.
Epilepsy research, 101(3), 268-276 (2012-05-15)
Organophosphates (OPs) inhibit the enzyme cholinesterase and cause accumulation of acetylcholine, and are known to cause seizures and status epilepticus (SE) in humans. The animal models of SE caused by organophosphate analogs of insecticides are not well characterized. SE caused
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