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27102

Sigma-Aldrich

Acido citrico

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

Sinonimo/i:

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Formula condensata:
HOC(COOH)(CH2COOH)2 · H2O
Numero CAS:
5949-29-1
Peso molecolare:
210.14
Beilstein:
4018641
Numero CE:
201-069-1
Numero MDL:
MFCD00149972
Codice UNSPSC:
12352100
ID PubChem:
57648219
NACRES:
NA.21

Grado

puriss.

Livello qualitativo

200

Saggio

99.5-100.5% (based on anhydrous substance)

Forma fisica

grit

Qualità

meets analytical specification of Ph. Eur., BP, USP, E330

Impurezze

residual solvents, complies
≤0.0005% heavy metals (as Pb)
7.5-8.8% water (Karl Fischer)

Residuo alla calcinazione

≤0.05% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

Anioni in tracce

chloride (Cl-): ≤50 mg/kg
oxalate (as oxalic acid): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

Cationi in tracce

As: ≤1 mg/kg
Ca: ≤200 mg/kg
Cu: ≤10 mg/kg
Fe: ≤10 mg/kg
Hg: ≤1 mg/kg
Pb: ≤1 mg/kg
Zn: ≤10 mg/kg

Compatibilità

complies for appearance of solution
complies for identity (IR)
complies for reaction against H2SO4

Stringa SMILE

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
YASYEJJMZJALEJ-UHFFFAOYSA-N

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Descrizione generale

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1

Applicazioni

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319,H335

Classi di pericolo

Eye Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

345.0 °F - closed cup

Punto d’infiammabilità (°C)

173.9 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
BCCK3277
BCCH5300
BCCG2090
BCCD2310
BCBT5913

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Sigma-Aldrich

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Supelco

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Sigma-Aldrich

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Sodio citrato tribasico

Acido citrico anhydrous for synthesis

Sigma-Aldrich

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Acido citrico

S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
Enthalpy of solution of oxalic, succinic, adipic, maleic, malic, tartaric, and citric acids, oxalic acid dihydrate, and citric acid monohydrate in water at 298.15K.
Apelblat A.
The Journal of Chemical Thermodynamics, 18(4), 351-357 (1986)
Carolina Ganss et al.
PloS one, 10(6), e0123889-e0123889 (2015-06-16)
For preventing erosive wear in dentine, coating with adhesives has been suggested as an alternative to fluoridation. However, clinical studies have revealed limited efficacy. As there is first evidence that Sn(2+) increases bond strength of the adhesive Clearfil SE (Kuraray)
T Ulens et al.
Journal of animal science, 93(2), 627-636 (2014-12-31)
This study evaluated the effect of feed form and grinding intensity of the pig diet and the interaction between both on the particulate matter (PM) concentrations inside a pig nursery and the growth performances of weanling pigs. Four diets were
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